Rabbit CMIP Polyclonal Antibody | anti-CMIP antibody

CMIP Antibody (C-term)

Cat. Num. AAA288490

• Gene Names: CMIP; TCMIP
• Reactivity: Human (Predicted Reactivity: Mouse, Xenopus)
• Applications: ELISA, Western Blot
• Purity: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Synonyms: CMIP, Antibody; CMIP Antibody (C-term); C-Maf-inducing protein; c-Mip; Truncated c-Maf-inducing protein; Tc-Mip; CMIP; KIAA1694; TCMIP; anti-CMIP antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Mouse, Xenopus)
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: This CMIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-764 amino acids from the C-terminal region of human CMIP.
• Purity/Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Positions: 735-764
• Sequence Length: 620

• Applicable Applications for anti-CMIP antibody: ELISA, WB (Western Blot)
• Function: Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.
• Cellular Location: Nucleus. Cytoplasm. Note=Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS) (PubMed:12939343) (PubMed:15616553). Detected in nuclear and cytoplasmic compartments during MCNS relapse (PubMed:12939343) (PubMed:15616553). Expressed in cytoplasm only during MCNS remission and absent in normal patients (PubMed:12939343)
• Tissue Location: Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(CMIP Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CMIP antibody detected the CMIP protein (arrow).)

Related Product Information for anti-CMIP antibody

CMIP plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.

Product Categories/Family for anti-CMIP antibody

Immunology

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Audard, V., et al. Blood 115(18):3756-3762(2010)
Kamal, M., et al. FEBS Lett. 584(3):500-506(2010)
Zhang, S.Y., et al. Sci Signal 3 (122), RA39 (2010) :
Newbury, D.F., et al. Am. J. Hum. Genet. 85(2):264-272(2009)

NCBI and Uniprot Product Information

• NCBI GI #: 29789255
• NCBI GeneID: 80790
• NCBI Accession #: NP_085132.1; NP_938204.2
• NCBI GenBank Nucleotide #: NM_030629.2
• UniProt Accession #: Q8IY22; Q9C0G9
• Molecular Weight: 86331
• NCBI Official Full Name: C-Maf-inducing protein isoform Tc-Mip
• NCBI Official Synonym Full Names: c-Maf inducing protein
• NCBI Official Symbol: CMIP
• NCBI Official Synonym Symbols: TCMIP
• NCBI Protein Information: C-Maf-inducing protein
• UniProt Protein Name: C-Maf-inducing protein
• UniProt Gene Name: CMIP
• UniProt Synonym Gene Names: KIAA1694; TCMIP; c-Mip; Tc-Mip
• UniProt Entry Name: CMIP_HUMAN