Rabbit CNGA2 Polyclonal Antibody | anti-CNGA2 antibody

CNGA2 Antibody (N-term)

Cat. Num. AAA290150

• Gene Names: CNGA2; CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA
• Reactivity: Human (Predicted Reactivity: Bovine, Mouse, Rabbit, Rat)
• Applications: Flow Cytometry, Functional Assay, ELISA, Western Blot
• Purity: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Synonyms: CNGA2, Antibody; CNGA2 Antibody (N-term); Cyclic nucleotide-gated olfactory channel; Cyclic nucleotide-gated cation channel 2; Cyclic nucleotide-gated channel alpha-2; CNG channel alpha-2; CNG-2; CNG2; CNGA2; CNCA; CNCA1; CNCG2; anti-CNGA2 antibody

• Host: Rabbit
• Reactivity: Human (Predicted Reactivity: Bovine, Mouse, Rabbit, Rat)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This CNGA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the N-terminal region of human CNGA2.
• Purity/Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Positions: 75-102
• Sequence Length: 664

• Applicable Applications for anti-CNGA2 antibody: FCM/FACS (Flow Cytometry), ELISA, WB (Western Blot)
• Function: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)- dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations.
• Cellular Location: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q00195}; Multi-pass membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

FCM/FACS (Flow Cytometry)

(CNGA2 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

WB (Western Blot)

(Western blot analysis of CNGA2 Antibody (N-term) in K562 cell line lysates (35ug/lane). CNGA2 (arrow) was detected using the purified Pab.)

Related Product Information for anti-CNGA2 antibody

CNGA2 represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation.

Product Categories/Family for anti-CNGA2 antibody

Cardiovascular; Neuroscience

References

Qu, W., et al. J. Gen. Physiol. 127(4):375-389(2006)
Hofmann, F., et al. Pharmacol. Rev. 57(4):455-462(2005)
Yoo, D., et al. J. Biol. Chem. 279(8):6863-6873(2004)

NCBI and Uniprot Product Information

• NCBI GI #: 42718011
• NCBI GeneID: 1260
• NCBI Accession #: NP_005131.1
• NCBI GenBank Nucleotide #: NM_005140.1
• UniProt Accession #: Q16280; A0AVD0
• Molecular Weight: 76048
• NCBI Official Full Name: cyclic nucleotide-gated olfactory channel
• NCBI Official Synonym Full Names: cyclic nucleotide gated channel alpha 2
• NCBI Official Symbol: CNGA2
• NCBI Official Synonym Symbols: CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA
• NCBI Protein Information: cyclic nucleotide-gated olfactory channel
• UniProt Protein Name: Cyclic nucleotide-gated olfactory channel
• UniProt Gene Name: CNGA2
• UniProt Synonym Gene Names: CNCA; CNCA1; CNCG2; CNG channel alpha-2; CNG-2; CNG2
• UniProt Entry Name: CNGA2_HUMAN