Application Data
(A: NIH/3T3 B: 293TFig: Western blot analysis on Hela using anti-COX-1 polyclonal antibody)
anti-Human, Mouse COX-1 Polyclonal Antibody | anti-COX-1 antibody
COX-1 Antibody
Gene Names
PTGS1; COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
Reactivity
Human, Mouse
Applications
Immunocytochemistry, Western Blot
Purity
Affinity purified
Synonyms
COX-1, Antibody; COX-1 Antibody; anti-COX-1 antibody
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of COX-1.
Purity/Purification
Affinity purified
Form/Format
1*TBS (pH7.4), 0.5%BSA, 25% Glycerol.
Sequence Length
599
Applicable Applications for anti-COX-1 antibody
ICC (Immunocytochemistry), WB (Western Blot)
Preservative
0.05% Sodium Azide.
Cellular Localization
Microsome Membrane; ER Membrane; Peripheral Membrane Protein
Positive Control
NIH/3T3
Preparation and Storage
Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.
Application Data
(A: NIH/3T3 B: 293TFig: Western blot analysis on Hela using anti-COX-1 polyclonal antibody)
Application Data
(A: NIH/3T3 B: 293TFig: Western blot analysis on Hela using anti-COX-1 polyclonal antibody)
Application Data
Application Data
Related Product Information for anti-COX-1 antibody
Cyclooxygenase-1(Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid. Cox1 is expressed constitutively in most tissues, while Cox2 expression is induced by lipopolysaccaride (LPS) and peptoglycan (PGN). PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk 1/2 at Tyr204). Both Cox1 and Cox2 play a role in the neuropathology of Alzheimer's disease by potentiating gamma-secretase activity and beta-amyloid generation. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain.
References
1. Sakamoto C. Roles of COX-1 and COX-2 in gastrointestinal pathophysiology. J Gastroenterol, 1998, 33(5)?618 2. Lee C, Chen KW, Sheu FS, et al. Studies of a tumor-associated antigen, COX-1, recognized by a monoclonal antibody. Cancer Immunol Immunother, 1992, 35(1)?19 3. Takahashi Y., Ueda N., et al.; "Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase)."; Biochem. Biophys. Res. Commun. 182:433-438(1992).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
~72kDa
NCBI Official Full Name
prostaglandin G/H synthase 1 isoform 1
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1
NCBI Official Symbol
PTGS1
NCBI Official Synonym Symbols
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
NCBI Protein Information
prostaglandin G/H synthase 1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Gene Name
PTGS1
UniProt Synonym Gene Names
COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1
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Product Notes
The COX-1 ptgs1 (Catalog #AAA111069) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The COX-1 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's COX-1 can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the COX-1 ptgs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COX-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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