IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human heart tissue using AAA231462 at dilution of 1:100)
Rabbit anti-Human, Mouse CRBN Polyclonal Antibody | anti-CRBN antibody
CRBN Antibody
Reactivity
Human, Mouse
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Antigen Affinity Purified
Synonyms
CRBN, Antibody; CRBN Antibody; Protein cereblon; CRBN; AD-006; anti-CRBN antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Sequence Length
441
Applicable Applications for anti-CRBN antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Species
Human
Immunogen
Recombinant human Protein cereblon protein (N-280AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human heart tissue using AAA231462 at dilution of 1:100)
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human heart tissue using AAA231462 at dilution of 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human thyroid tissue using AAA231462 at dilution of 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human thyroid tissue using AAA231462 at dilution of 1:100)
WB (Western Blot)
(Western blotAll lanes: CRBN antibody at 5.28 ug/mlLane 1: Mouse liver tissueLane 2: A375 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 51 kDaObserved band size: 51 kDa)
WB (Western Blot)
(Western blotAll lanes: CRBN antibody at 5.28 ug/mlLane 1: Mouse liver tissueLane 2: A375 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 51 kDaObserved band size: 51 kDa)
Related Product Information for anti-CRBN antibody
Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
50,475 Da
NCBI Official Full Name
protein cereblon isoform 2
UniProt Protein Name
Protein cereblon
UniProt Gene Name
CRBN
UniProt Entry Name
CRBN_HUMAN
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Product Notes
The CRBN crbn (Catalog #AAA231462) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CRBN Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CRBN can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the CRBN crbn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRBN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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