Rabbit anti-Human CTLA4 Polyclonal Antibody | anti-CTLA4 antibody

CTLA4 Polyclonal Antibody

Cat. Num. AAA179752

• Gene Names: Ctla4; Cd152; Ly-56; Ctla-4
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: CTLA4, Antibody; CTLA4 Polyclonal Antibody; Ctla4; Ly-56; GRD; Cytotoxic T-lymphocyte protein; Cytotoxic T-lymphocyte-associated antigen; IDDM; CELIAC; CELIAC3; CTLA-4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; GRD4; GSE; IDDM12; Cd152; anti-CTLA4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-CTLA4 antibody: IHC (Immunohistochemistry)
• Immunogen: Recombinant Mouse CTLA4 protein expressed by Mammalian
• Preparation and Storage: Store at -20 degree C Valid for 12 months. Avoid freeze/thaw cycles. Protected from prolonged exposure to light.

IHC (Immunohiostchemistry)

(Immunohistochemistry of paraffin-embedded Human tonsil using CTLA4 Polyclonal Antibody at dilution of 1:1800.)

IHC (Immunohistochemistry)

(Immunohistochemistry of paraffin-embedded Human colon carcinoma using CTLA4 Polyclonal Antibody at dilution of 1:1800.)

Related Product Information for anti-CTLA4 antibody

CTLA-4 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. CTLA-4 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CTLA-4 and CD28 are composed of a single Ig V?like extracellular domain, a transmembrane domain and an intracellular domain. CTLA-4 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2. CTLA-4 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CTLA-4 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CTLA-4 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with 20-100-fold higher affinity than CD28. The physiological role of CTLA-4 in T cell costimulation is currently being studied.

Product Categories/Family for anti-CTLA4 antibody

Polyclonal Antibodies; Primary Antibodies; Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 117606
• NCBI GeneID: 12477
• UniProt Accession #: P09793; Q9QZZ7
• Molecular Weight: 24,993 Da
• NCBI Official Full Name: Cytotoxic T-lymphocyte protein 4
• NCBI Official Synonym Full Names: cytotoxic T-lymphocyte-associated protein 4
• NCBI Official Symbol: Ctla4
• NCBI Official Synonym Symbols: Cd152; Ly-56; Ctla-4
• NCBI Protein Information: cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4
• UniProt Protein Name: Cytotoxic T-lymphocyte protein 4
• UniProt Gene Name: Ctla4
• UniProt Synonym Gene Names: Cd152; CTLA-4
• UniProt Entry Name: CTLA4_MOUSE