IHC (Immunohiostchemistry)
(Anti-DCC antibody, AAA45454, IHC(P)IHC(P): Human Intestinal Cancer Tissue)
Rabbit DCC Polyclonal Antibody | anti-DCC antibody
Anti-DCC antibody
Gene Names
DCC; CRC18; CRCR1; MRMV1; IGDCC1; NTN1R1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
DCC, Antibody; Anti-DCC antibody; Netrin receptor DCC; deleted in colorectal carcinoma; Colorectal cancer related chromosome sequence 18 antibody; Colorectal cancer suppressor antibody; CRC 18 antibody; CRC18 antibody; CRCR 1 antibody; CRCR1 antibody; DCC antibody; DCC_HUMAN antibody; Deleted in colorectal cancer protein antibody; Deleted in colorectal carcinoma antibody; Immunoglobulin superfamily DCC subclass member 1 antibody; Netrin receptor DCC antibody; Tumor suppressor protein DCC antibody; anti-DCC antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Liquid; Contains 20mM PBS, 50% glycerol, 0.02% NaN3
Concentration
200ug/ml (varies by lot)
Sequence Length
1447
Applicable Applications for anti-DCC antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human DCC (162-178aa EVIGEPMPTIHWQKNQQ), identical to the related mouse sequence, and different from the related rat sequence by one amino acid.
Preparation and Storage
At -20°C for 1 year, 4°C for one month. Avoid repeated freezing and thawing.
IHC (Immunohiostchemistry)
(Anti-DCC antibody, AAA45454, IHC(P)IHC(P): Human Intestinal Cancer Tissue)
IHC (Immunohiostchemistry)
(Anti-DCC antibody, AAA45454, IHC(P)IHC(P): Human Intestinal Cancer Tissue)
WB (Western Blot)
(Anti-DCC antibody, AAA45454, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue LysateLane 3: U87 Cell LysateLane 4: SW620 Cell LysateLane 5: COLO320 Cell LysateLane 6: 293T Cell LysateLane 7: HELA Cell Lysate)
WB (Western Blot)
(Anti-DCC antibody, AAA45454, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Mouse Brain Tissue LysateLane 3: U87 Cell LysateLane 4: SW620 Cell LysateLane 5: COLO320 Cell LysateLane 6: 293T Cell LysateLane 7: HELA Cell Lysate)
Related Product Information for anti-DCC antibody
DCC(Deleted IN Colorectal Carcinoma) also known as CRC18 or CRCR1. The DCC gene encodes a functional receptor for netrin and mediates axon outgrowth and the steering response. Heterozygous loss-of-function mutations in DCC can result in congenital mirror movements. Alterations in DCC occur frequently in colorectal cancer. Studying a YAC contig containing the entire DCC coding region, they showed that the DCC gene spans approximately 1.4 Mb. Vogelstein(1995) stated that the precise location of the DCC gene was though to be 18q21.3. DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. DCC protein could be detected in varying abundance in all specimens of normal colonic mucosa analyzed as well as in all specimens of adenomatous polyps, colorectal carcinoma and colorectal liver metastases. DCC may function as a tumor-suppressor protein by inducing apoptosis in settings in which ligand is unavailable(for example, during metastasis or tumor growth beyond local blood supply) through functional caspase cascades by a mechanism that requires cleavage of DCC at asp1290. Stein et al.(2001) concluded that DCC plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Netrin receptor DCC
NCBI Official Synonym Full Names
DCC netrin 1 receptor
NCBI Official Symbol
DCC
NCBI Official Synonym Symbols
CRC18; CRCR1; MRMV1; IGDCC1; NTN1R1
NCBI Protein Information
netrin receptor DCC; colorectal tumor suppressor; colorectal cancer suppressor; tumor suppressor protein DCC; deleted in colorectal carcinoma; deleted in colorectal cancer protein; immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1
UniProt Protein Name
Netrin receptor DCC
UniProt Gene Name
DCC
UniProt Synonym Gene Names
IGDCC1
UniProt Entry Name
DCC_HUMAN
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Product Notes
The DCC dcc (Catalog #AAA45454) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DCC antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DCC can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the DCC dcc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DCC, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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