IHC (Immunohiostchemistry)
(DSG1 Antibody (Center) (AAA285311)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DSG1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human DSG1 Polyclonal Antibody | anti-DSG1 antibody
DSG1 Antibody (Center)
Gene Names
DSG1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
DSG1, Antibody; DSG1 Antibody (Center); Desmoglein-1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen; DSG1; CDHF4; anti-DSG1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This DSG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-499 amino acids from the Central region of human DSG1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
471-499
Sequence Length
408
Applicable Applications for anti-DSG1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(DSG1 Antibody (Center) (AAA285311)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DSG1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(DSG1 Antibody (Center) (AAA285311)immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DSG1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(DSG1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the DSG1 antibody detected the DSG1 protein (arrow).)
WB (Western Blot)
(DSG1 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the DSG1 antibody detected the DSG1 protein (arrow).)
Related Product Information for anti-DSG1 antibody
Desmosomes are cell-cell junctions between epithelial,
myocardial and certain other cell types. Desmoglein 1 is a
calcium-binding transmembrane glycoprotein component of desmosomes
in vertebrate epithelial cells. Currently, three desmoglein
subfamily members have been identified and all are members of the
cadherin cell adhesion molecule superfamily. These desmoglein gene
family members are located in a cluster on chromosome 18. The
protein encoded by this gene has been identified as the autoantigen
of the autoimmune skin blistering disease pemphigus foliaceus.
myocardial and certain other cell types. Desmoglein 1 is a
calcium-binding transmembrane glycoprotein component of desmosomes
in vertebrate epithelial cells. Currently, three desmoglein
subfamily members have been identified and all are members of the
cadherin cell adhesion molecule superfamily. These desmoglein gene
family members are located in a cluster on chromosome 18. The
protein encoded by this gene has been identified as the autoantigen
of the autoimmune skin blistering disease pemphigus foliaceus.
Product Categories/Family for anti-DSG1 antibody
References
Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010)
Naoe, Y., et al. J. Dermatol. Sci. 57(3):192-198(2010)
Qian, Y., et al. J. Invest. Dermatol. 129(12):2823-2834(2009)
Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)
Getsios, S., et al. J. Cell Biol. 185(7):1243-1258(2009)
Naoe, Y., et al. J. Dermatol. Sci. 57(3):192-198(2010)
Qian, Y., et al. J. Invest. Dermatol. 129(12):2823-2834(2009)
Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)
Getsios, S., et al. J. Cell Biol. 185(7):1243-1258(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
113748
NCBI Official Full Name
desmoglein-1 preproprotein
NCBI Official Synonym Full Names
desmoglein 1
NCBI Official Symbol
DSG1
NCBI Official Synonym Symbols
DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA
NCBI Protein Information
desmoglein-1
UniProt Protein Name
Desmoglein-1
UniProt Gene Name
DSG1
UniProt Synonym Gene Names
CDHF4; DG1; DGI
UniProt Entry Name
DSG1_HUMAN
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Product Notes
The DSG1 dsg1 (Catalog #AAA285311) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 471-499. The DSG1 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DSG1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the DSG1 dsg1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DSG1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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