IF (Immunofluorescence)
(Confocal immunofluorescent analysis of DVL1 Antibody (Center) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Rabbit DVL1 Polyclonal Antibody | anti-DVL1 antibody
DVL1 Antibody (Center)
Gene Names
DVL1; DVL; DRS2; DVL1L1; DVL1P1
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Applications
Immunofluorescence, Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
DVL1, Antibody; DVL1 Antibody (Center); Segment polarity protein dishevelled homolog DVL-1; Dishevelled-1; DSH homolog 1; DVL1; anti-DVL1 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This DVL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 442-470 amino acids from the Central region of human DVL1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.4 (varies by lot)
Sequence Positions
442-470
Sequence Length
670
Applicable Applications for anti-DVL1 antibody
IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of DVL1 Antibody (Center) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IF (Immunofluorescence)
(Confocal immunofluorescent analysis of DVL1 Antibody (Center) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
IHC (Immunohiostchemistry)
(DVL1 Antibdy (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DVL1 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(DVL1 Antibdy (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DVL1 Antibdy (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(DVL1 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the DVL1 antibody detected the DVL1 protein (arrow).)
WB (Western Blot)
(DVL1 Antibody (Center) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the DVL1 antibody detected the DVL1 protein (arrow).)
Related Product Information for anti-DVL1 antibody
DVL1, the human homolog of the Drosophila dishevelled gene
(dsh) encodes a cytoplasmic phosphoprotein that regulates cell
proliferation, acting as a transducer molecule for developmental
processes, including segmentation and neuroblast specification.
DVL1 is a candidate gene for neuroblastomatous transformation. The
Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A
have been mapped to the same region as DVL1. The phenotypes of
these diseases may be consistent with defects which might be
expected from aberrant expression of a DVL gene during development.
(dsh) encodes a cytoplasmic phosphoprotein that regulates cell
proliferation, acting as a transducer molecule for developmental
processes, including segmentation and neuroblast specification.
DVL1 is a candidate gene for neuroblastomatous transformation. The
Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A
have been mapped to the same region as DVL1. The phenotypes of
these diseases may be consistent with defects which might be
expected from aberrant expression of a DVL gene during development.
Product Categories/Family for anti-DVL1 antibody
References
Metcalfe, C., et al. J. Cell. Sci. 123 (PT 9), 1588-1599 (2010) :
Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)
Varelas, X., et al. Dev. Cell 18(4):579-591(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) :
Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)
Varelas, X., et al. Dev. Cell 18(4):579-591(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
75187
NCBI Official Full Name
segment polarity protein dishevelled homolog DVL-1
NCBI Official Synonym Full Names
dishevelled segment polarity protein 1
NCBI Official Symbol
DVL1
NCBI Official Synonym Symbols
DVL; DRS2; DVL1L1; DVL1P1
NCBI Protein Information
segment polarity protein dishevelled homolog DVL-1
UniProt Protein Name
Segment polarity protein dishevelled homolog DVL-1
UniProt Gene Name
DVL1
UniProt Synonym Gene Names
Dishevelled-1
UniProt Entry Name
DVL1_HUMAN
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Product Notes
The DVL1 dvl1 (Catalog #AAA290317) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 442-470. The DVL1 Antibody (Center) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's DVL1 can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the DVL1 dvl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DVL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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