IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human pancreas tissue using AAA118256 at dilution 1:100)
Rabbit anti-Human E3 ubiquitin-protein ligase CBL-C Polyclonal Antibody | anti-CBLC antibody
Rabbit anti-human E3 ubiquitin-protein ligase CBL-C polyclonal Antibody(CBLC)
Gene Names
CBLC; CBL-3; RNF57; CBL-SL
Reactivity
Human
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Antigen Affinity Purified
Synonyms
E3 ubiquitin-protein ligase CBL-C, Antibody; Rabbit anti-human E3 ubiquitin-protein ligase CBL-C polyclonal Antibody(CBLC); RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Signal transduction protein CBL-C; CBLC; CBL3; RNF57; anti-CBLC antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Sequence Length
428
Applicable Applications for anti-CBLC antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human E3 ubiquitin-protein ligase CBL-C protein (245-474aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8372 / sc-8371
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human pancreas tissue using AAA118256 at dilution 1:100)
IHC (Immunohistochemisry)
(Immunohistochemistry of paraffin-embedded human pancreas tissue using AAA118256 at dilution 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human breast cancer using AAA118256 at dilution 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human breast cancer using AAA118256 at dilution 1:100)
WB (Western Blot)
(All lanes: E3 ubiquitin-protein ligase CBL-C antibody at 14ug/mlLane 1:A549 whole cell lysateLane 2:Hela whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 53,48 kDaObserved band size: 52 kDa)
WB (Western Blot)
(All lanes: E3 ubiquitin-protein ligase CBL-C antibody at 14ug/mlLane 1:A549 whole cell lysateLane 2:Hela whole cell lysateSecondaryGoat polyclonal to rabbit at 1/10000 dilutionPredicted band size: 53,48 kDaObserved band size: 52 kDa)
Related Product Information for anti-CBLC antibody
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
47,418 Da
NCBI Official Full Name
E3 ubiquitin-protein ligase CBL-C isoform 2
NCBI Official Synonym Full Names
Cbl proto-oncogene C, E3 ubiquitin protein ligase
NCBI Official Symbol
CBLC
NCBI Official Synonym Symbols
CBL-3; RNF57; CBL-SL
NCBI Protein Information
E3 ubiquitin-protein ligase CBL-C
UniProt Protein Name
E3 ubiquitin-protein ligase CBL-C
UniProt Gene Name
CBLC
UniProt Synonym Gene Names
CBL3; RNF57
UniProt Entry Name
CBLC_HUMAN
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Product Notes
The CBLC cblc (Catalog #AAA118256) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human E3 ubiquitin-protein ligase CBL-C polyclonal Antibody(CBLC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's E3 ubiquitin-protein ligase CBL-C can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the CBLC cblc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase CBL-C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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