WB (Western Blot)
(Anti-ECSCR Antibody (C-term) at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 21 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit anti-Human ECSCR Polyclonal Antibody | anti-ECSCR antibody
ECSCR Antibody (C-term)
Gene Names
ECSCR; ARIA; ECSM2
Reactivity
Human
Applications
ELISA, Western Blot
Synonyms
ECSCR, Antibody; ECSCR Antibody (C-term); Endothelial cell-specific chemotaxis regulator; Apoptosis regulator through modulating IAP expression; ARIA; Endothelial cell-specific molecule 2; ECSCR; ECSM2; anti-ECSCR antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This ECSCR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the C-terminal region of human ECSCR.
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
137-165
Sequence Length
205
Applicable Applications for anti-ECSCR antibody
ELISA, WB (Western Blot)
Antigen Region
137-165
Function
Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.
Cellular Location
Cell membrane; Single-pass type I membrane protein. Cytoplasm
Tissue Location
Highest expression in endothelial cells. Also detected in vascular smooth muscle, macrophages, lymphocytes, and mast cells.
Preparation and Storage
Maintain refrigerated at 2-8°C. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(Anti-ECSCR Antibody (C-term) at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 21 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
WB (Western Blot)
(Anti-ECSCR Antibody (C-term) at 1:1000 dilution + A549 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 21 kDa Blocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-ECSCR antibody
The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it may be involved in cell shape changes and EGF-induced cell migration. This gene could play a role in angiogenesis-related diseases.
References
Ikeda, K., et al. Proc. Natl. Acad. Sci. U.S.A. 106(20):8227-8232(2009)
Ma, F., et al. Genes Cells 14(3):281-293(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Armstrong, L.J., et al. Arterioscler. Thromb. Vasc. Biol. 28(9):1640-1646(2008)
Ma, F., et al. Genes Cells 14(3):281-293(2009)
Graubert, T.A., et al. PLoS ONE 4 (2), E4583 (2009) :
Armstrong, L.J., et al. Arterioscler. Thromb. Vasc. Biol. 28(9):1640-1646(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated MW: 21295
NCBI Official Full Name
endothelial cell-specific chemotaxis regulator isoform 1
NCBI Official Synonym Full Names
endothelial cell surface expressed chemotaxis and apoptosis regulator
NCBI Official Symbol
ECSCR
NCBI Official Synonym Symbols
ARIA; ECSM2
NCBI Protein Information
endothelial cell-specific chemotaxis regulator
UniProt Protein Name
Endothelial cell-specific chemotaxis regulator
UniProt Gene Name
ECSCR
UniProt Synonym Gene Names
ECSM2; ARIA
UniProt Entry Name
ECSCR_HUMAN
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Product Notes
The ECSCR ecscr (Catalog #AAA286000) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 137-165. The ECSCR Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's ECSCR can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the ECSCR ecscr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ECSCR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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