Sheep anti-Human, Mouse ENDOTHELIN B RECEPTOR Polyclonal Antibody | anti-Ednrb antibody

SHEEP ANTI RAT ENDOTHELIN B RECEPTOR (C-TERMINAL)

Cat. Num. AAA50072

• Gene Names: Ednrb; Etb; Ednra
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Immunoprecipitation, Immunofluorescence
• Synonyms: ENDOTHELIN B RECEPTOR, Antibody; SHEEP ANTI RAT ENDOTHELIN B RECEPTOR (C-TERMINAL); anti-Ednrb antibody

• Host: Sheep
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item specifically recognises an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. This item recognizes epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. This item does not block the binding of endothelins. This item is reported as suitable for use in immunocytochemistry on acetone fixed cells.
• Form/Format: Purified IgG - liquid
• Concentration: IgG concentration 1.41mg/ml (varies by lot)
• Sequence Length: 442

• Applicable Applications for anti-Ednrb antibody: IHC (Immunohistochemistry), IP (Immunoprecipitation), IF (Immunofluorescence)
• Perservative Stabilizers: <0.1% Sodium Azide (NaN3)
• Immunogen: Keyhole limpet haemocyanin (KLH) conjugated C-terminal peptide KANDHGYDNFRSSNN corresponding to amino acids 424 to 437 of rat endothelin B receptor.
• Buffer Solution: Phosphate buffered saline
• Antiserum Preparation: Antiserum to rat ET-B (CT) was raised by repeated immunization of sheep with highly purified antigen. Purified IgG was prepared by affinity chromatography.
• Target Species: Rat
• Species Cross-Reactivity: Mouse, Human; N.B: Antibody reactivity and working conditions may vary between species. Cross reactivity is dervied from testing within the QC internal labs, peer reviewed publications or personal communications from the originators.
• Preparation and Storage: Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

Related Product Information for anti-Ednrb antibody

Sheep anti Rat endothelin B receptor antibody recognizes an epitope within the C-terminal (CT) region of endothelin B receptor (ET-B), a widely distributed transmembrane protein and member of the G-protein coupled receptor 1 family, which acts as a non-specific receptor for endothelin 1, 2, and 3, and mediates its action by G protein association and activation of a phosphatidylinositol-calcium second messenger system. Sheep anti Rat endothelin B receptor antibody (AAR43) recognizes epitopes on the cytoplasmic side of the receptor and therefore the cell membrane must be permeable to the antibody. AAR43 does not block the binding of endothelins.

Sheep anti Rat endothelin B receptor antibody (AAR43) is suitable for use in immunocytochemistry on acetone fixed cells.

NCBI and Uniprot Product Information

• NCBI GI #: 8393333
• NCBI GeneID: 50672
• NCBI Accession #: NP_059029.1
• NCBI GenBank Nucleotide #: NM_017333.1
• NCBI Official Full Name: endothelin B receptor
• NCBI Official Synonym Full Names: endothelin receptor type B
• NCBI Official Symbol: Ednrb
• NCBI Official Synonym Symbols: Etb; Ednra
• NCBI Protein Information: endothelin B receptor; ET-B; ET-BR; endothelin receptor non-selective type; endothelin-B receptor
• UniProt Protein Name: Endothelin B receptor
• UniProt Gene Name: Ednrb
• UniProt Synonym Gene Names: ET-B; ET-BR
• UniProt Entry Name: EDNRB_RAT