WB (Western Blot)
(Anti-ErbB 4 antibody, AAA45414, Western blottingLane 1: HELA Cell LysateLane 2: U87 Cell LysateLane 3: NEURO Cell Lysate)
Rabbit ErbB 4 Polyclonal Antibody | anti-ERBB4 antibody
Anti-ErbB 4 antibody
Gene Names
ERBB4; HER4; ALS19; p180erbB4
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Immunogen affinity purified.
Synonyms
ErbB 4, Antibody; Anti-ErbB 4 antibody; Receptor tyrosine-protein kinase erbB-4; v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian); 4ICD antibody; Avian erythroblastic leukemia viral oncogene homolog 4 antibody; Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody; E4ICD antibody; EC 2.7.10.1 antibody; ErbB4 antibody; ERBB4 intracellular domain antibody; ERBB4_HUMAN antibody; HER 4 antibody; HER4 antibody; Mer4 antibody; MGC138404 antibody; Oncogene ERBB4 antibody; P180erbB4 antibody; Proto-oncogene-like protein c-ErbB-4 antibody; Receptor protein tyrosine kinase erbB 4 precursor antibody; Receptor tyrosine protein kinase erbB 4 antibody; s80HER4 antibody; Tyrosine kinase type cell surface receptor HER4 antibody; Tyrosine kinase-type cell surface receptor HER4 antibody; v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody; v erb a erythroblastic leukemia viral oncogene homolog 4 antibody; v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian) antibody; V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody; Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody; Verba erythroblastic leukemia viral oncogene homolog 4 antibody; VERBB2 antibody; anti-ERBB4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
1308
Applicable Applications for anti-ERBB4 antibody
WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4 (35-51aa KLSSLSDLEQQYRALRK), identical to the related rat and mouse sequences.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Anti-ErbB 4 antibody, AAA45414, Western blottingLane 1: HELA Cell LysateLane 2: U87 Cell LysateLane 3: NEURO Cell Lysate)
WB (Western Blot)
(Anti-ErbB 4 antibody, AAA45414, Western blottingLane 1: HELA Cell LysateLane 2: U87 Cell LysateLane 3: NEURO Cell Lysate)
WB (Western Blot)
(Anti-ErbB 4 antibody, AAA45414, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant human ERRB4, 40.6KD(162aa tag+M1-P200)Lane 1: Recombinant Human ERRB4 Protein 10ngLane 2: Recombinant Human ERRB4 Protein 5ngLane 3: Recombinant Human ERRB4 Protein 2.5ngLane 4: Recombinant Human ERRB4 Protein 1.25ng)
WB (Western Blot)
(Anti-ErbB 4 antibody, AAA45414, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant human ERRB4, 40.6KD(162aa tag+M1-P200)Lane 1: Recombinant Human ERRB4 Protein 10ngLane 2: Recombinant Human ERRB4 Protein 5ngLane 3: Recombinant Human ERRB4 Protein 2.5ngLane 4: Recombinant Human ERRB4 Protein 1.25ng)
WB (Western Blot)
(Anti-ErbB 4 antibody, AAA45414, Western blottingLane 1: A549 Cell LysateLane 2: HELA Cell Lysate)
WB (Western Blot)
(Anti-ErbB 4 antibody, AAA45414, Western blottingLane 1: A549 Cell LysateLane 2: HELA Cell Lysate)
Related Product Information for anti-ERBB4 antibody
Description: Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human, Mouse, Rat.
Background: ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.
Background: ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
143,968 Da
NCBI Official Full Name
Receptor tyrosine-protein kinase erbB-4
NCBI Official Synonym Full Names
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
NCBI Official Symbol
ERBB4
NCBI Official Synonym Symbols
HER4; ALS19; p180erbB4
NCBI Protein Information
receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-4
UniProt Gene Name
ERBB4
UniProt Synonym Gene Names
HER4; 4ICD; E4ICD
UniProt Entry Name
ERBB4_HUMAN
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Product Notes
The ERBB4 erbb4 (Catalog #AAA45414) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-ErbB 4 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ErbB 4 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the ERBB4 erbb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ErbB 4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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