Rabbit FAIM Polyclonal Antibody | anti-FAIM antibody

FAIM antibody

Cat. Num. AAA301196

• Gene Names: FAIM; FAIM1
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: FAIM, Antibody; FAIM antibody; FAIM; FAIM1; anti-FAIM antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total FAIM antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 213

• Applicable Applications for anti-FAIM antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human FAIM.
• Target Name: FAIM
• Preparation and Storage: Store at -20 degree C

IHC (Immunohiostchemistry)

(Immunohistochemistry analysis of paraffin-embedded human rectal cancer using FAIM antibody at dilution of 1:200 (x400 lens))

WB (Western Blot)

(Western blot analysis of 293 cell lysate using FAIM antibody.)

Related Product Information for anti-FAIM antibody

FAIM (Fas apoptosis inhibitory molecule) was identified as a protein that was inducibly expressed in B lymphocytes resistant to Fas-mediated apoptosis (1). Expression of FAIM inhibits receptor-mediated apoptosis in B cells as well as other cell types (1-3). FAIM is expressed in germinal center B cells, is positively regulated by IRF-4, and is also capable of inducing IRF-4 expression in a feed-forward mechanism (4). FAIM also regulates T cell receptor-mediated apoptosis by modulating Akt activation and Nur77 expression (2). Knockout mice for FAIM show an increased sensitivity to Fas-mediated apoptosis within B and T cells as well as hepatocytes (5). An alternatively spliced form of FAIM, termed FAIM-L, is found predominantly in the brain (6). In the nervous system, the originally identified FAIM does not appear to play a role in apoptosis, but rather can promote neurite outgrowth through the activation of Erk and NF-kB pathways (7). In contrast, FAIM-L does inhibit neuronal cell death triggered by death receptors (3).

Product Categories/Family for anti-FAIM antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 74271911
• NCBI GeneID: 55179
• NCBI Accession #: NP_001028202.1
• NCBI GenBank Nucleotide #: NM_001033030.1
• UniProt Accession #: Q9NVQ4; Q6IAN2
• Molecular Weight: 22,626 Da
• NCBI Official Full Name: fas apoptotic inhibitory molecule 1 isoform a
• NCBI Official Synonym Full Names: Fas apoptotic inhibitory molecule
• NCBI Official Symbol: FAIM
• NCBI Official Synonym Symbols: FAIM1
• NCBI Protein Information: fas apoptotic inhibitory molecule 1
• UniProt Protein Name: Fas apoptotic inhibitory molecule 1
• UniProt Gene Name: FAIM
• UniProt Synonym Gene Names: FAIM1
• UniProt Entry Name: FAIM1_HUMAN