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ICC (Immunocytochemistry)
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Rabbit FBXL2 Polyclonal Antibody | anti-FBXL2 antibody

FBXL2 Antibody

Gene Names
FBXL2; FBL2; FBL3
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunocytochemistry, Immunohistochemistry
Purity
ProA affinity purified
Synonyms
FBXL2, Antibody; FBXL2 Antibody; DKFZP564P0622 antibody; F box and leucine rich repeat protein 2 antibody; F box protein containing leucine rich repeats antibody; F box protein FBL2/FBL3 antibody; F box/LRR repeat protein 2 antibody; F-box and leucine-rich repeat protein 2 antibody; F-box protein FBL2/FBL3 antibody; F-box/LRR-repeat protein 2 antibody; FBL 2 antibody; FBL 3 antibody; FBL2 antibody; FBL3 antibody; FBXL 2 antibody; FBXL2 antibody; FBXL2_HUMAN antibody; anti-FBXL2 antibody
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For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
ProA affinity purified
Form/Format
1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-FBXL2 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)
Application Notes
WB: 1:1000-1:10,000
IHC: 1:50-1:200
ICC: 1:50-1:200
Immunogen
Recombinant protein
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.

ICC (Immunocytochemistry)

(ICC staining FBXL2 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

ICC (Immunocytochemistry)

(ICC staining FBXL2 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

ICC (Immunocytochemistry)

(ICC staining FBXL2 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.)

IHC (Immunohistchemistry)

(Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-FBXL2 antibody. Counter stained with hematoxylin.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-FBXL2 antibody. Counter stained with hematoxylin.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-FBXL2 antibody. Counter stained with hematoxylin.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-FBXL2 antibody. Counter stained with hematoxylin.)

WB (Western Blot)

(Western blot analysis of FBXL2 on rat liver tissue lysate using anti-FBXL2 antibody at 1/10, 000 dilution.)

WB (Western Blot)

(Western blot analysis of FBXL2 on different lysates using anti-FBXL2 antibody at 1/1, 000 dilution. Positive control�� Lane1: Mouse liver tissue Lane2: Mouse heart tissue Lane3: SiHa)

Related Product Information for anti-FBXL2 antibody
Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin (By similarity). Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G (0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication.
Product Categories/Family for anti-FBXL2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
39,613 Da
NCBI Official Full Name
F-box/LRR-repeat protein 2 isoform 2
NCBI Official Synonym Full Names
F-box and leucine-rich repeat protein 2
NCBI Official Symbol
FBXL2
NCBI Official Synonym Symbols
FBL2; FBL3
NCBI Protein Information
F-box/LRR-repeat protein 2; F-box protein FBL2/FBL3; F-box protein containing leucine-rich repeats
UniProt Protein Name
F-box/LRR-repeat protein 2
UniProt Gene Name
FBXL2
UniProt Entry Name
FBXL2_HUMAN

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Product Notes

The FBXL2 fbxl2 (Catalog #AAA29885) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FBXL2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FBXL2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC). WB: 1:1000-1:10,000 IHC: 1:50-1:200 ICC: 1:50-1:200. Researchers should empirically determine the suitability of the FBXL2 fbxl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FBXL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.