WB (Western Blot)
(Figure 1. Western blot analysis of FDPS using anti-FDPS antibody.)
Rabbit anti-Human, Rat FDPS/FPS Polyclonal Antibody | anti-FDPS antibody
Anti-FDPS/FPS Antibody
Gene Names
FDPS; FPS; FPPS; POROK9
Reactivity
Human, Rat
Applications
ELISA, Flow Cytometry, Functional Assay, Western Blot
Purity
Immunogen affinity purified.
Synonyms
FDPS/FPS, Antibody; Anti-FDPS/FPS Antibody; Farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase; FDPS; KIAA1293; anti-FDPS antibody
Host
Rabbit
Reactivity
Human, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
419
Applicable Applications for anti-FDPS antibody
ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), WB (Western Blot)
Immunogen
E Coli-derived human FDPS/FPS recombinant protein (Position: S29-Q397).
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
Store at -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen store at -20 degree C for a longer time. Avoid repeated freezing and thawing.
WB (Western Blot)
(Figure 1. Western blot analysis of FDPS using anti-FDPS antibody.)
WB (Western Blot)
(Figure 1. Western blot analysis of FDPS using anti-FDPS antibody.)
FCM/FACS (Flow Cytometry)
FCM/FACS (Flow Cytometry)
Related Product Information for anti-FDPS antibody
Description: Rabbit IgG polyclonal antibody for FDPS/FPS detection. Tested with WB, FCM, Direct ELISA in Human;Rat.
Background: Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene. It is mapped to 1q22. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
Background: Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene. It is mapped to 1q22. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.
References
1. Heinzmann, C., Clarke, C. F., Klisak, I., Mohandas, T., Sparkes, R. S., Edwards, P. A., Lusis, A. J. Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. Genomics 5: 493-500, 1989.
2. Krisans, S. K., Ericsson, J., Edwards, P. A., Keller, G. A. Farnesyl-diphosphate synthase is localized in peroxisomes. J. Biol. Chem. 269: 14165-14169, 1994.
3. Scott, A. F. Personal Communication. Baltimore, Md. 11/9/2006.
2. Krisans, S. K., Ericsson, J., Edwards, P. A., Keller, G. A. Farnesyl-diphosphate synthase is localized in peroxisomes. J. Biol. Chem. 269: 14165-14169, 1994.
3. Scott, A. F. Personal Communication. Baltimore, Md. 11/9/2006.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
NCBI Official Full Name
Farnesyl pyrophosphate synthase
NCBI Official Synonym Full Names
farnesyl diphosphate synthase
NCBI Official Symbol
FDPS
NCBI Official Synonym Symbols
FPS; FPPS; POROK9
NCBI Protein Information
farnesyl pyrophosphate synthase
UniProt Protein Name
Farnesyl pyrophosphate synthase
UniProt Gene Name
FDPS
UniProt Synonym Gene Names
FPS; KIAA1293; FPP synthase; FPS
UniProt Entry Name
FPPS_HUMAN
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Product Notes
The FDPS fdps (Catalog #AAA125437) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-FDPS/FPS Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FDPS/FPS can be used in a range of immunoassay formats including, but not limited to, ELISA (Direct ELISA), FCM/FACS (Flow Cytometry), WB (Western Blot). Researchers should empirically determine the suitability of the FDPS fdps for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FDPS/FPS, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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