WB (Western Blot)
(Anti- FE65 antibody, Western blottingAll lanes: Anti at 0.5ug/mlWB: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 77KDObserved bind size: 77KD)
FE65 Polyclonal Antibody | anti-FE65 antibody
Anti-FE65 Antibody
Gene Names
APBB1; RIR; FE65; MGC:9072
Reactivity
MousePredicted to work with: Human
Applications
Western Blot
Purity
Immunogen Affinity Purified
Synonyms
FE65, Antibody; Anti-FE65 Antibody; Amyloid beta A4 precursor protein-binding family B member 1; Adaptor protein FE65a2; Amyloid beta (A4) precursor protein binding family B member 1; Amyloid Beta A4 Precursor Protein Binding Family B; Amyloid beta A4 precursor protein binding family B member 1; Amyloid beta precursor protein binding family B member 1; APBB 1; APBB1; APBB1_HUMAN; FE 65; Fe65 protein; Protein Fe65; RIR; stat like protein; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); anti-FE65 antibody
Reactivity
Mouse
Predicted to work with: Human
Predicted to work with: Human
Clonality
Polyclonal
Isotype
IgG
Specificity
No cross reactivity with other proteins.
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
710
Applicable Applications for anti-FE65 antibody
WB (Western Blot)
Immunogen
E Coli-derived human FE65 recombinant protein (Position: Q295-A613). Human FE65 shares 95%and 96% amino acid (aa) sequence identity with mouse and rat FE65, respectively.
Reconstitution
0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquoted and stored frozen at -20°C for a longer time.
Avoid repeated freezing and thawing.
Avoid repeated freezing and thawing.
WB (Western Blot)
(Anti- FE65 antibody, Western blottingAll lanes: Anti at 0.5ug/mlWB: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 77KDObserved bind size: 77KD)
WB (Western Blot)
(Anti- FE65 antibody, Western blottingAll lanes: Anti at 0.5ug/mlWB: Mouse Brain Tissue Lysate at 50ugPredicted bind size: 77KDObserved bind size: 77KD)
Related Product Information for anti-FE65 antibody
Description: Rabbit IgG polyclonal antibody for Amyloid beta A4 precursor protein-binding family B member 1(APBB1) detection. Tested with WB in Human;Mouse.
Background: APBB1 is also known as RIR or FE65. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Background: APBB1 is also known as RIR or FE65. The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
References
1. Chen GB, et al. Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers. Hum Genet, 2008 Nov. 2. Cheung HN, et al. FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth. FASEB J, 2014 Jan. 3. Ward MW, et al. The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics. J Neurochem, 2010 Apr.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
amyloid beta A4 protein-binding family B member 1 isoform a
NCBI Official Synonym Full Names
amyloid beta precursor protein binding family B member 1
NCBI Official Symbol
APBB1
NCBI Official Synonym Symbols
RIR; FE65; MGC:9072
NCBI Protein Information
amyloid beta A4 precursor protein-binding family B member 1
UniProt Protein Name
Amyloid beta A4 precursor protein-binding family B member 1
UniProt Gene Name
APBB1
UniProt Synonym Gene Names
FE65; RIR
UniProt Entry Name
APBB1_HUMAN
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Product Notes
The FE65 apbb1 (Catalog #AAA46586) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-FE65 Antibody reacts with Mouse Predicted to work with: Human and may cross-react with other species as described in the data sheet. AAA Biotech's FE65 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the FE65 apbb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FE65, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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