IHC (Immunohiostchemistry)
(FXYD5 Antibody (Center) (AAA284778)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FXYD5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit anti-Human FXYD5 Polyclonal Antibody | anti-FXYD5 antibody
FXYD5 Antibody (Center)
Gene Names
FXYD5; RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241
Reactivity
Human
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
FXYD5, Antibody; FXYD5 Antibody (Center); FXYD domain-containing ion transport regulator 5; Dysadherin; FXYD5; DYSAD; IWU1; anti-FXYD5 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This FXYD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the Central region of human FXYD5.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
71-100
Sequence Length
107
Applicable Applications for anti-FXYD5 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(FXYD5 Antibody (Center) (AAA284778)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FXYD5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(FXYD5 Antibody (Center) (AAA284778)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FXYD5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(FXYD5 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FXYD5 antibody detected the FXYD5 protein (arrow).)
WB (Western Blot)
(FXYD5 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FXYD5 antibody detected the FXYD5 protein (arrow).)
Related Product Information for anti-FXYD5 antibody
This gene encodes a member of a family of small membrane
proteins that share a 35-amino acid signature sequence domain,
beginning with the sequence PFXYD and containing 7 invariant and 6
highly conserved amino acids. The approved human gene nomenclature
for the family is FXYD-domain containing ion transport regulator.
Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
also known as the gamma subunit of the Na,K-ATPase, regulates the
properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
induce channel activity in experimental expression systems.
Transmembrane topology has been established for two family members
(FXYD1 and FXYD2), with the N-terminus extracellular and the
C-terminus on the cytoplasmic side of the membrane. This gene
product, FXYD5, is a glycoprotein that functions in the
up-regulation of chemokine production, and it is involved in the
reduction of cell adhesion via its ability to down-regulate
E-cadherin. It also promotes metastasis, and has been linked to a
variety of cancers. Alternative splicing results in multiple
transcript variants. [RefSeq curation by Kathleen J. Sweadner,
Ph.D., sweadner@helix.mgh.harvard.edu.].
proteins that share a 35-amino acid signature sequence domain,
beginning with the sequence PFXYD and containing 7 invariant and 6
highly conserved amino acids. The approved human gene nomenclature
for the family is FXYD-domain containing ion transport regulator.
Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2,
also known as the gamma subunit of the Na,K-ATPase, regulates the
properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma),
FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to
induce channel activity in experimental expression systems.
Transmembrane topology has been established for two family members
(FXYD1 and FXYD2), with the N-terminus extracellular and the
C-terminus on the cytoplasmic side of the membrane. This gene
product, FXYD5, is a glycoprotein that functions in the
up-regulation of chemokine production, and it is involved in the
reduction of cell adhesion via its ability to down-regulate
E-cadherin. It also promotes metastasis, and has been linked to a
variety of cancers. Alternative splicing results in multiple
transcript variants. [RefSeq curation by Kathleen J. Sweadner,
Ph.D., sweadner@helix.mgh.harvard.edu.].
Product Categories/Family for anti-FXYD5 antibody
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ono, K., et al. Anticancer Res. 30(9):3273-3278(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liang, J.F., et al. Pathol. Res. Pract. 205(7):445-450(2009)
Batistatou, A., et al. Endocr. Pathol. 19(3):197-202(2008)
Ono, K., et al. Anticancer Res. 30(9):3273-3278(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liang, J.F., et al. Pathol. Res. Pract. 205(7):445-450(2009)
Batistatou, A., et al. Endocr. Pathol. 19(3):197-202(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
19472
NCBI Official Full Name
FXYD domain-containing ion transport regulator 5
NCBI Official Synonym Full Names
FXYD domain containing ion transport regulator 5
NCBI Official Symbol
FXYD5
NCBI Official Synonym Symbols
RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241
NCBI Protein Information
FXYD domain-containing ion transport regulator 5
UniProt Protein Name
FXYD domain-containing ion transport regulator 5
UniProt Gene Name
FXYD5
UniProt Synonym Gene Names
DYSAD; IWU1
UniProt Entry Name
FXYD5_HUMAN
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Product Notes
The FXYD5 fxyd5 (Catalog #AAA284778) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 71-100. The FXYD5 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FXYD5 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the FXYD5 fxyd5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FXYD5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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