Rabbit GEMIN6 Polyclonal Antibody | anti-GEMIN6 antibody

GEMIN6 Antibody

Cat. Num. AAA328661

• Reactivity: Human, Mouse, Rat; Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
• Applications: Western Blot
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: GEMIN6, Antibody; GEMIN6 Antibody; FLJ23459; Gem (nuclear organelle) associated protein 6; Gem-associated protein 6; GEMI6; GEMI6_HUMAN; Gemin-6; Gemin6; SIP2; anti-GEMIN6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat; Predicted: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GEMIN6 Antibody detects endogenous levels of GEMIN6.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 167

• Applicable Applications for anti-GEMIN6 antibody: WB (Western Blot)
• Immunogen: A synthesized peptide derived from human GEMIN6.
• Fragment: Fab Fragment
• Conjugate: Unconjugated
• Subcellular Location: Nucleus
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

WB (Western Blot)

(Western blot analysis of extracts from HEK-293 cells, using GEMIN6 Antibody. The lane on the left was treated with blocking peptide.)

Related Product Information for anti-GEMIN6 antibody

Description: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

Subunit Structure: Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts directly with GEMIN7, SNRPB, SNRPD2, SNRPD3 and SNRPE.

NCBI and Uniprot Product Information

• NCBI GI #: 41393577
• NCBI GeneID: 79833
• NCBI Accession #: NP_079051.9
• NCBI GenBank Nucleotide #: NP_079051.9
• UniProt Accession #: Q8WXD5
• Molecular Weight: Observed: 19 kDa; Predicted: 19 kDa
• NCBI Official Full Name: gem-associated protein 6
• NCBI Official Synonym Full Names: gem nuclear organelle associated protein 6
• NCBI Official Symbol: GEMIN6
• NCBI Protein Information: gem-associated protein 6
• UniProt Protein Name: Gem-associated protein 6
• UniProt Gene Name: GEMIN6
• UniProt Synonym Gene Names: Gemin-6