IHC (Immunohiostchemistry)
(GP2 Antibody-Anti-GP2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
Rabbit anti-Human GP2 Polyclonal Antibody | anti-GP2 antibody
GP2 Rabbit anti-Human Polyclonal (aa182-231) Antibody
Gene Names
GP2; ZAP75
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, Immunohistochemistry
Purity
Immunoaffinity purified
Synonyms
GP2, Antibody; GP2 Rabbit anti-Human Polyclonal (aa182-231) Antibody; PathPlus GP2 Antibody (aa182-231); GP2; gp2; ZAP75; anti-GP2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Human GP2
Purity/Purification
Immunoaffinity purified
Form/Format
PBS, 0.09% sodium azide, 2% sucrose
Concentration
0.5mg/ml (varies by lot)
Applicable Applications for anti-GP2 antibody
WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry)
Target
Human GP2
Immunogen
Synthetic peptide located between aa182-231 of human GP2 (P55259, NP_001007242). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Galago (100%); Elephant, Horse (92%); Marmoset, Mouse, Opossum (91%); Rat, Bat (83%).
Conjugation
Unconjugated
Epitope
aa182-231
Preparation and Storage
Short term: Store at 2-8 degree C. Long term: Aliquot and store at -20 degree C. Avoid freeze/thaw cycles.
IHC (Immunohiostchemistry)
(GP2 Antibody-Anti-GP2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
IHC (Immunohiostchemistry)
(GP2 Antibody-Anti-GP2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(GP2 Antibody-Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
WB (Western Blot)
(GP2 Antibody-Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%. This image was taken for the unconjugated form of this product. Other forms have not been tested.)
Related Product Information for anti-GP2 antibody
GP2 antibody is an unconjugated rabbit polyclonal antibody to GP2 (aa182-231) from human. It is reactive with human, rat, bovine and other species. Validated for IHC and WB. Cited in 1 publication.
GP2 (pancreatic zymogen granule membrane glycoprotein 2, ZAP75) is a protein found in great abundance in the pancreatic secretory granule membrane that is involved in regulating the innate immune response, is capable of sensing microbiota and is thought to function to prevent binding of bacteria to host epithelial cells. It is released into the intestine after being cleaved from the secretory granule membrane in the pancreas. It is a receptor for type 1 fimbriae (T1F) protein expressing bacteria such as Salmonella and Escherichia coli. It is expressed on multipotent progenitor cells in the developing pancreas. It is thus considered to be a useful cell-surface biomarker for embryonic pancreatic progenitors in vivo, with utility in the purification of embryonic stem cell-derived progenitors or in the evaluation of pancreatic differentiation in vitro. In immunohistochemistry, GP2 has cytoplasmic positivity in the pancreas as well as secretory positivity in the intestine and other tissues.
GP2 (pancreatic zymogen granule membrane glycoprotein 2, ZAP75) is a protein found in great abundance in the pancreatic secretory granule membrane that is involved in regulating the innate immune response, is capable of sensing microbiota and is thought to function to prevent binding of bacteria to host epithelial cells. It is released into the intestine after being cleaved from the secretory granule membrane in the pancreas. It is a receptor for type 1 fimbriae (T1F) protein expressing bacteria such as Salmonella and Escherichia coli. It is expressed on multipotent progenitor cells in the developing pancreas. It is thus considered to be a useful cell-surface biomarker for embryonic pancreatic progenitors in vivo, with utility in the purification of embryonic stem cell-derived progenitors or in the evaluation of pancreatic differentiation in vitro. In immunohistochemistry, GP2 has cytoplasmic positivity in the pancreas as well as secretory positivity in the intestine and other tissues.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Front. Microbiol. 2018, DOI:10.3389/fmicb.2018.01905; Nat Commun 8, 331 (2017), DOI:10.1038/s41467-017-00561-0; J Immunol. 2012 Sep 15;189(6):2774-83, PMID: 22891285;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
43,039 Da
NCBI Official Full Name
pancreatic secretory granule membrane major glycoprotein GP2 isoform 2
NCBI Official Synonym Full Names
glycoprotein 2 (zymogen granule membrane)
NCBI Official Symbol
GP2
NCBI Official Synonym Symbols
ZAP75
NCBI Protein Information
pancreatic secretory granule membrane major glycoprotein GP2; pancreatic zymogen granule membrane protein GP-2; pancreatic zymogen granule membrane associated protein GP2
UniProt Protein Name
Pancreatic secretory granule membrane major glycoprotein GP2
UniProt Gene Name
GP2
UniProt Entry Name
GP2_HUMAN
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Product Notes
The GP2 gp2 (Catalog #AAA162566) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GP2 Rabbit anti-Human Polyclonal (aa182-231) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GP2 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the GP2 gp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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