Rabbit GRIA3 Polyclonal Antibody | anti-GRIA3 antibody

GRIA3 Antibody

Cat. Num. AAA303343

• Gene Names: GRIA3; GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: GRIA3, Antibody; GRIA3 Antibody; GLUR3; GLURC; GluA3; MRX94; GLUR-C; anti-GRIA3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total GRIA3 protein.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 894

• Applicable Applications for anti-GRIA3 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human GRIA3.
• Target Name: GRIA3
• Preparation and Storage: Store at -20 degree C

IF (Immunofluorescence)

(Immunofluorescence analysis of U2OS cell using GRIA3 antibody. Blue: DAPI for nuclear staining.)

IHC (Immunohistochemistry)

(Immunohistochemical analysis of paraffin-embedded rat spleen using GRIA3 antibody at dilution of 1:200 (400x lens).)

IHC (Immunohistochemisry)

(Immunohistochemical analysis of paraffin-embedded human stomach cancer using GRIA3 antibody at dilution of 1:200 (400x lens).)

IHC (Immunohiostchemistry)

(Immunohistochemical analysis of paraffin-embedded human thyroid cancer using GRIA3 antibody at dilution of 1:200 (400x lens).)

WB (Western Blot)

(Western blot analysis of brian cell lysate using GRIA3 antibody.)

Related Product Information for anti-GRIA3 antibody

AMPA- (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), kainite- and NMDA- (N-methyl-D-aspartate) receptors are the three main families of ionotropic glutamate-gated ion channels. AMPA receptors (AMPARs) are comprised of four subunits (GluR 1-4) that assemble as homo- or hetero-tetramers and mediate the majority of fast excitatory transmissions in the CNS. AMPARs are implicated in synapse formation, stabilization and plasticity. Post-transcriptional modifications (alternative splicing and nuclear RNA editing) and post-translational modifications (glycosylation, phoshorylation) result in a very large number of permutations, fine-tuning the kinetic properties of AMPARs (1). GluR 3 knockout mice exhibited normal basal synaptic transmission and long-term depression (LTD) but enhanced long-term potentiation (LTP). In contrast, GluR 2/3 double knockout mice are impaired in basal synaptic transmission (2). Aberrant GluR 3 expression or activity is implicated in a number of diseases, including autoimmune epilepsy, X-linked mental retardation, Rett's syndrome, amyotrophic lateral sclerosis and Alzheimer disease (3).

Product Categories/Family for anti-GRIA3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 163659858
• NCBI GeneID: 2892
• NCBI Accession #: NP_000819.3
• NCBI GenBank Nucleotide #: NM_000828.4
• UniProt Accession #: P42263; Q4VXD5; Q4VXD6; Q9HDA0; Q9HDA1; Q9HDA2; Q9P0H1; D3DTF1
• Molecular Weight: 101,228 Da
• NCBI Official Full Name: glutamate receptor 3 isoform 2
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, AMPA 3
• NCBI Official Symbol: GRIA3
• NCBI Official Synonym Symbols: GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3
• NCBI Protein Information: glutamate receptor 3
• UniProt Protein Name: Glutamate receptor 3
• UniProt Gene Name: GRIA3
• UniProt Synonym Gene Names: GLUR3; GLURC; GluR-3; GluA3
• UniProt Entry Name: GRIA3_HUMAN