WB (Western Blot)
(GRIN2C Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the GRIN2C antibody detected the GRIN2C protein (arrow).)
Rabbit anti-Mouse GRIN2C Polyclonal Antibody | anti-GRIN2C antibody
GRIN2C Antibody (Center)
Gene Names
GRIN2C; NR2C; GluN2C; NMDAR2C
Reactivity
Mouse
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
GRIN2C, Antibody; GRIN2C Antibody (Center); Glutamate receptor ionotropic; NMDA 2C; GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C; GRIN2C; anti-GRIN2C antibody
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This GRIN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the Central region of human GRIN2C.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
567-595
Sequence Length
1233
Applicable Applications for anti-GRIN2C antibody
ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Function
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
Cellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
Tissue Location
Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(GRIN2C Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the GRIN2C antibody detected the GRIN2C protein (arrow).)
WB (Western Blot)
(GRIN2C Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the GRIN2C antibody detected the GRIN2C protein (arrow).)
Related Product Information for anti-GRIN2C antibody
N-methyl-D-aspartate (NMDA) receptors are a class of
ionotropic glutamate receptors. NMDA channel has been shown to be
involved in long-term potentiation, an activity-dependent increase
in the efficiency of synaptic transmission thought to underlie
certain kinds of memory and learning. NMDA receptor channels are
heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and
1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B
(GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by
RefSeq].
ionotropic glutamate receptors. NMDA channel has been shown to be
involved in long-term potentiation, an activity-dependent increase
in the efficiency of synaptic transmission thought to underlie
certain kinds of memory and learning. NMDA receptor channels are
heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and
1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B
(GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by
RefSeq].
Product Categories/Family for anti-GRIN2C antibody
References
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
Shi, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (7), 1270-1277 (2008) :
Self, R.L., et al. Brain Res. 995(1):39-45(2004)
Krapivinsky, G., et al. Neuron 40(4):775-784(2003)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
Shi, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (7), 1270-1277 (2008) :
Self, R.L., et al. Brain Res. 995(1):39-45(2004)
Krapivinsky, G., et al. Neuron 40(4):775-784(2003)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
134209
NCBI Official Full Name
glutamate receptor ionotropic, NMDA 2C isoform 1
NCBI Official Synonym Full Names
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
NCBI Official Symbol
GRIN2C
NCBI Official Synonym Symbols
NR2C; GluN2C; NMDAR2C
NCBI Protein Information
glutamate receptor ionotropic, NMDA 2C
UniProt Protein Name
Glutamate receptor ionotropic, NMDA 2C
UniProt Gene Name
GRIN2C
UniProt Synonym Gene Names
NMDAR2C; GluN2C; NMDAR2C; NR2C
UniProt Entry Name
NMDE3_HUMAN
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Product Notes
The GRIN2C grin2c (Catalog #AAA285762) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 567-595. The GRIN2C Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GRIN2C can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the GRIN2C grin2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRIN2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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