Rabbit GRK6 Polyclonal Antibody | anti-GRK6 antibody

GRK6 Antibody

Cat. Num. AAA40778

• Gene Names: GRK6; GPRK6
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: GRK6 antibody is affinity chromatography purified via peptide column.
• Synonyms: GRK6, Antibody; GRK6 Antibody; GRK6; GPRK6; G protein-coupled receptor kinase 6; G protein-coupled receptor kinase GRK6; anti-GRK6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.
• Purity/Purification: GRK6 antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 576

• Applicable Applications for anti-GRK6 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6.
• Buffer: GRK6 antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: GRK6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

IF (Immunofluorescence)

(Immunofluorescence of GRK6 in human small intestine tissue with GRK6 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of GRK6 in human small intestine tissue with GRK6 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of GRK6 in rat small intestine tissue lysate with GRK6 antibody at 1 μg/ml.)

Related Product Information for anti-GRK6 antibody

The G protein-coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).

NCBI and Uniprot Product Information

• NCBI GI #: 51896039
• NCBI GeneID: 2870
• NCBI Accession #: NP_001004106
• NCBI GenBank Nucleotide #: NM_001004106.2
• UniProt Accession #: P43250; O60541; Q13652
• Molecular Weight: Predicted: 63 kDa; ; Observed: 63 kDa
• NCBI Official Full Name: G protein-coupled receptor kinase 6 isoform A
• NCBI Official Synonym Full Names: G protein-coupled receptor kinase 6
• NCBI Official Symbol: GRK6
• NCBI Official Synonym Symbols: GPRK6
• NCBI Protein Information: G protein-coupled receptor kinase 6
• UniProt Protein Name: G protein-coupled receptor kinase 6
• UniProt Gene Name: GRK6
• UniProt Synonym Gene Names: GPRK6
• UniProt Entry Name: GRK6_HUMAN