FCM/FACS (Flow Cytometry)
(GUCY2D Antibody (Center) flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Rabbit anti-Human GUCY2D Polyclonal Antibody | anti-GUCY2D antibody
GUCY2D Antibody (Center)
Gene Names
GUCY2D; LCA; CYGD; LCA1; RCD2; CORD5; CORD6; GUC2D; ROSGC; retGC; GUC1A4; RETGC-1; ROS-GC1
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
GUCY2D, Antibody; GUCY2D Antibody (Center); Retinal guanylyl cyclase 1; RETGC-1; Guanylate cyclase 2D; retinal; Rod outer segment membrane guanylate cyclase; ROS-GC; GUCY2D; CORD6; GUC1A4; GUC2D; RETGC; RETGC1; anti-GUCY2D antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This GUCY2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-570 amino acids from the Central region of human GUCY2D.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.4 (varies by lot)
Sequence Positions
540-570
Sequence Length
1103
Applicable Applications for anti-GUCY2D antibody
FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
FCM/FACS (Flow Cytometry)
(GUCY2D Antibody (Center) flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
FCM/FACS (Flow Cytometry)
(GUCY2D Antibody (Center) flow cytometric analysis of Ramos cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
IHC (Immunohiostchemistry)
(GUCY2D Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human thyroid tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GUCY2D Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(GUCY2D Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human thyroid tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GUCY2D Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(GUCY2D Antibody (Center) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the GUCY2D antibody detected the GUCY2D protein (arrow).)
WB (Western Blot)
(GUCY2D Antibody (Center) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the GUCY2D antibody detected the GUCY2D protein (arrow).)
Related Product Information for anti-GUCY2D antibody
This gene encodes a retina-specific guanylate cyclase,
which is a member of the membrane guanylyl cyclase family. Like
other membrane guanylyl cyclases, this enzyme has a hydrophobic
amino-terminal signal sequence followed by a large extracellular
domain, a single membrane spanning domain, a kinase homology
domain, and a guanylyl cyclase catalytic domain. In contrast to
other membrane guanylyl cyclases, this enzyme is not activated by
natriuretic peptides. Mutations in this gene result in Leber
congenital amaurosis and cone-rod dystrophy-6 diseases. [provided
by RefSeq].
which is a member of the membrane guanylyl cyclase family. Like
other membrane guanylyl cyclases, this enzyme has a hydrophobic
amino-terminal signal sequence followed by a large extracellular
domain, a single membrane spanning domain, a kinase homology
domain, and a guanylyl cyclase catalytic domain. In contrast to
other membrane guanylyl cyclases, this enzyme is not activated by
natriuretic peptides. Mutations in this gene result in Leber
congenital amaurosis and cone-rod dystrophy-6 diseases. [provided
by RefSeq].
Product Categories/Family for anti-GUCY2D antibody
References
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Pasadhika, S., et al. Invest. Ophthalmol. Vis. Sci. 51(5):2608-2614(2010)
Sundaresan, P., et al. Mol. Vis. 15, 1781-1787 (2009) :
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Pasadhika, S., et al. Invest. Ophthalmol. Vis. Sci. 51(5):2608-2614(2010)
Sundaresan, P., et al. Mol. Vis. 15, 1781-1787 (2009) :
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
120059
NCBI Official Full Name
retinal guanylyl cyclase 1
NCBI Official Synonym Full Names
guanylate cyclase 2D, membrane (retina-specific)
NCBI Official Symbol
GUCY2D
NCBI Official Synonym Symbols
LCA; CYGD; LCA1; RCD2; CORD5; CORD6; GUC2D; ROSGC; retGC; GUC1A4; RETGC-1; ROS-GC1
NCBI Protein Information
retinal guanylyl cyclase 1
UniProt Protein Name
Retinal guanylyl cyclase 1
UniProt Gene Name
GUCY2D
UniProt Synonym Gene Names
CORD6; GUC1A4; GUC2D; RETGC; RETGC1; RETGC-1; ROS-GC
UniProt Entry Name
GUC2D_HUMAN
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Product Notes
The GUCY2D gucy2d (Catalog #AAA286259) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 540-570. The GUCY2D Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GUCY2D can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the GUCY2D gucy2d for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GUCY2D, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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