IHC (Immunohiostchemistry)
(Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 ug/mL.)
Rabbit HAP1 Polyclonal Antibody | anti-HAP1 antibody
HAP1 Antibody
Gene Names
HAP1; HLP; HAP2; HIP5; hHLP1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
HAP1, Antibody; HAP1 Antibody; Huntingtin-associated protein 1, neuroan 1, HLP, HIP5; anti-HAP1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
671
Applicable Applications for anti-HAP1 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 19 amino acid peptide from near the center of human HAP1.
Target Name
HAP1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
IHC (Immunohiostchemistry)
(Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 ug/mL.)
IHC (Immunohiostchemistry)
(Immunohistochemistry of HAP1 in human brain tissue with HAP1 antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of HAP1 in mouse brain tissue lysate with HAP1 antibody at (A) 0.5 and (B) 1 ug/mL.)
Related Product Information for anti-HAP1 antibody
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
Product Categories/Family for anti-HAP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
67,582 Da
NCBI Official Full Name
huntingtin-associated protein 1
NCBI Official Synonym Full Names
huntingtin-associated protein 1
NCBI Official Symbol
HAP1
NCBI Official Synonym Symbols
HLP; HAP2; HIP5; hHLP1
NCBI Protein Information
huntingtin-associated protein 1
UniProt Protein Name
Huntingtin-associated protein 1
UniProt Gene Name
HAP1
UniProt Synonym Gene Names
HAP2; HLP1; HAP-1
UniProt Entry Name
HAP1_HUMAN
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Product Notes
The HAP1 hap1 (Catalog #AAA303709) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HAP1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HAP1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the HAP1 hap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HAP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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