Rabbit anti-Human HDAC10 Polyclonal Antibody | anti-HDAC10 antibody

HDAC10 Antibody (N-term)

Cat. Num. AAA286962

• Gene Names: HDAC10; HD10
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: HDAC10, Antibody; HDAC10 Antibody (N-term); Histone deacetylase 10; HD10; HDAC10; anti-HDAC10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This HDAC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human HDAC10.
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 16-46
• Sequence Length: 649

• Applicable Applications for anti-HDAC10 antibody: ELISA, WB (Western Blot)
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(Western blot analysis of HDAC10 (arrow) using rabbit polyclonal HDAC10 Antibody (N-term) (RB02583). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the HDAC10 gene (Lane 2) (Origene Technologies).)

WB (Western Blot)

(Western blot analysis of anti-HDAC10 Pab in A375 cell line lysates. HDAC10(arrow) was detected using the purified Pab.)

Related Product Information for anti-HDAC10 antibody

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about two-fold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual
substrate specificity and function in vivo. HDAC8 interacts with PEPB2-MYH11, a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11 produced by the inversion Inv(16)(p13q22), a translocation associated with acute myeloid leukemia of M4EO subtype. The PEPB2-MYH1 fusion protein also interacts with RUNX1, a well known transcriptional regulator, suggesting that the interaction with HDAC8 may participate to convert RUNX1 into a constitutive transcriptional repressor.

Product Categories/Family for anti-HDAC10 antibody

Signal Transduction

References

Keedy, K.S. et al. J Virol. May; 83(10): 4749?756(2009).
Tong, J.J., et al., Nucleic Acids Res. 30(5):1114-1123 (2002).
Fischer, D.D., et al., J. Biol. Chem. 277(8):6656-6666 (2002).
Guardiola, A.R., et al., J. Biol. Chem. 277(5):3350-3356 (2002).
Kao, H.Y., et al., J. Biol. Chem. 277(1):187-193 (2002).

NCBI and Uniprot Product Information

• NCBI GI #: 226529806
• NCBI GeneID: 83933
• NCBI Accession #: NP_001152758.1; NP_114408.3
• NCBI GenBank Nucleotide #: NM_001159286.1
• UniProt Accession #: Q969S8; Q08AP4; Q6STF9; Q96P77; Q96P78; Q9H028; Q9UGX1; Q9UGX2
• Molecular Weight: 71445
• NCBI Official Full Name: histone deacetylase 10 isoform 2
• NCBI Official Synonym Full Names: histone deacetylase 10
• NCBI Official Symbol: HDAC10
• NCBI Official Synonym Symbols: HD10
• NCBI Protein Information: histone deacetylase 10
• UniProt Protein Name: Histone deacetylase 10
• UniProt Gene Name: HDAC10
• UniProt Synonym Gene Names: HD10
• UniProt Entry Name: HDA10_HUMAN