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ICC (Immunocytochemistry)
(Anti- HLA-C Picoband antibody, AAA46402,ICCICC: HELA Cell)
HLA-C Polyclonal Antibody | anti-HLA-C antibody
Anti-HLA-C Antibody
Gene Names
HLA-C; HLAC; HLC-C; D6S204; PSORS1; HLA-JY3
Reactivity
Human, Mouse, Rat
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Purity
Immunogen Affinity Purified
Synonyms
HLA-C, Antibody; Anti-HLA-C Antibody; MHC class I antigen; 1C07_HUMAN; Cw-7 alpha chain; D6S204; HLA class I histocompatibility antigen; HLA class I histocompatibility antigen, C alpha chain; HLA class I histocompatibility antigen, Cw-1 alpha chain; HLA-C antibodyHLA-C histocompatibility type; HLA-Cw; HLA-JY3; HLAC; HLC-C; human leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC class I antigen Cw 1; MHC class I antigen Cw*7; MHC class I antigen heavy chain HLA-C; PSORS1; anti-HLA-C antibody
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Immunogen Affinity Purified
Form/Format
Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Sequence Length
70
Applicable Applications for anti-HLA-C antibody
ICC (Immunocytochemistry), IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human HLA-C(38-62aa EYWDRETQKYKRQAQADRVNLRKLR).
Ig Type
Rabbit IgG
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquoted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ICC (Immunocytochemistry)
(Anti- HLA-C Picoband antibody, AAA46402,ICCICC: HELA Cell)
ICC (Immunocytochemistry)
(Anti- HLA-C Picoband antibody, AAA46402,ICCICC: HELA Cell)
IHC (Immunohistochemistry)
(Anti- HLA-C Picoband antibody, AAA46402,IHC(P)IHC(P): Human Lung Cancer Tissue)
IHC (Immunohistochemistry)
(Anti- HLA-C Picoband antibody, AAA46402,IHC(P)IHC(P): Human Lung Cancer Tissue)
IHC (Immunohistochemisry)
(Anti- HLA-C Picoband antibody, AAA46402,IHC(P)IHC(P): Rat Intestine Tissue)
IHC (Immunohistochemisry)
(Anti- HLA-C Picoband antibody, AAA46402,IHC(P)IHC(P): Rat Intestine Tissue)
IHC (Immunohiostchemistry)
(Anti- HLA-C Picoband antibody, AAA46402,IHC(P)IHC(P): Mouse Intestine Tissue)
IHC (Immunohiostchemistry)
(Anti- HLA-C Picoband antibody, AAA46402,IHC(P)IHC(P): Mouse Intestine Tissue)
WB (Western Blot)
(Anti- HLA-C Picoband antibody, AAA46402, Western blottingAll lanes: Anti HLA-C (AAA46402) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: U87 Whole Cell Lysate at 40ugLane 4: Rat Brain Tissue Lysate at 50ugLane 5: Rat Liver Tissue Lysate at 50ugPredicted bind size: 41KDObserved bind size: 41KD)
WB (Western Blot)
(Anti- HLA-C Picoband antibody, AAA46402, Western blottingAll lanes: Anti HLA-C (AAA46402) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: A549 Whole Cell Lysate at 40ugLane 3: U87 Whole Cell Lysate at 40ugLane 4: Rat Brain Tissue Lysate at 50ugLane 5: Rat Liver Tissue Lysate at 50ugPredicted bind size: 41KDObserved bind size: 41KD)
Related Product Information for anti-HLA-C antibody
Description: Rabbit IgG polyclonal antibody for MHC class I antigen(HLA-C) detection. Tested with WB, IHC-P, ICC in Human;Mouse;Rat.
Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
References
1. Ríos A, Rodríguez JM, Moya MR, Galindo PJ, Canteras M, Alvarez MR, Parrilla P (2006). "Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain.". Arch Surg 141 (2): 123-8. 2. Valés-Gómez M, Reyburn HT, Mandelboim M, Strominger JL (September 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity 9 (3): 337-44.
NCBI and Uniprot Product Information
NCBI GeneID
UniProt Accession #
Molecular Weight
8,415 Da
NCBI Official Synonym Full Names
major histocompatibility complex, class I, C
NCBI Official Symbol
HLA-C
NCBI Official Synonym Symbols
HLAC; HLC-C; D6S204; PSORS1; HLA-JY3
NCBI Protein Information
HLA class I histocompatibility antigen, Cw-1 alpha chain
UniProt Protein Name
MHC class I antigen
UniProt Gene Name
HLA-C
UniProt Entry Name
U5YBW8_HUMAN
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Product Notes
The HLA-C hla-c (Catalog #AAA46402) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-HLA-C Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HLA-C can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the HLA-C hla-c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HLA-C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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