IHC (Immunohiostchemistry)
(The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using 47723(HLA-DRB4 Antibody) at dilution 1/60.(Original magnification: 200))
Rabbit anti-Human HLA-DRB4 Polyclonal Antibody | anti-HLA-DRB4 antibody
HLA-DRB4 Antibody
Gene Names
HLA-DRB4; DR4; DRB4; HLA-DR4B
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Antigen affinity purification
Synonyms
HLA-DRB4, Antibody; HLA-DRB4 Antibody; DR4; DRB4; HLA-DR4B; anti-HLA-DRB4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
The antibody detects endogenous levels of total HLA-DRB4 protein.
Purity/Purification
Antigen affinity purification
Form/Format
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
1 mg/mL (varies by lot)
Sequence Length
266
Applicable Applications for anti-HLA-DRB4 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
Fusion protein of human HLA-DRB4
Immunogen Type
Peptide
Preparation and Storage
Store at -20 degree C.
IHC (Immunohiostchemistry)
(The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using 47723(HLA-DRB4 Antibody) at dilution 1/60.(Original magnification: 200))
IHC (Immunohiostchemistry)
(The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using 47723(HLA-DRB4 Antibody) at dilution 1/60.(Original magnification: 200))
SDS-PAGE
(Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell lysate, Primary antibody:47723(HLA-DRB4 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds)
SDS-PAGE
(Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell lysate, Primary antibody:47723(HLA-DRB4 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds)
Related Product Information for anti-HLA-DRB4 antibody
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Product Categories/Family for anti-HLA-DRB4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
30 kDa
NCBI Official Full Name
major histocompatibility complex, class II, DR beta 4
NCBI Official Synonym Full Names
major histocompatibility complex, class II, DR beta 4
NCBI Official Symbol
HLA-DRB4
NCBI Official Synonym Symbols
DR4; DRB4; HLA-DR4B
NCBI Protein Information
major histocompatibility complex, class II, DR beta 4
UniProt Protein Name
HLA class II histocompatibility antigen, DR beta 4 chain
UniProt Gene Name
HLA-DRB4
Similar Products
Product Notes
The HLA-DRB4 hla-drb4 (Catalog #AAA310815) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HLA-DRB4 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HLA-DRB4 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the HLA-DRB4 hla-drb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HLA-DRB4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.