IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.)
Rabbit anti-Human HMGCS1 Polyclonal Antibody | anti-HMGCS1 antibody
HMGCS1 Antibody
Gene Names
HMGCS1; HMGCS
Reactivity
Human
Applications
Immunohistochemistry, Western Blot
Purity
Antigen affinity purification.
Synonyms
HMGCS1, Antibody; HMGCS1 Antibody; HMGCS; anti-HMGCS1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total HMGCS1 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
2.3 mg/ml (varies by lot)
Sequence Length
520
Applicable Applications for anti-HMGCS1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Target Name
HMGCS1
Preparation and Storage
Store at -20 degree C
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.)
IHC (Immunohiostchemistry)
(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/40.)
Application Data
(Gel: 6%SDS-PAGE Lysates (from left to right): Human fetal liver tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds)
Application Data
(Gel: 6%SDS-PAGE Lysates (from left to right): Human fetal liver tissue Amount of lysate: 40ug per lane Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds)
Related Product Information for anti-HMGCS1 antibody
HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
Product Categories/Family for anti-HMGCS1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57,294 Da
NCBI Official Full Name
hydroxymethylglutaryl-CoA synthase, cytoplasmic
NCBI Official Synonym Full Names
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
NCBI Official Symbol
HMGCS1
NCBI Official Synonym Symbols
HMGCS
NCBI Protein Information
hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Protein Name
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
UniProt Gene Name
HMGCS1
UniProt Synonym Gene Names
HMGCS; HMG-CoA synthase
UniProt Entry Name
HMCS1_HUMAN
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Product Notes
The HMGCS1 hmgcs1 (Catalog #AAA302876) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HMGCS1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HMGCS1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the HMGCS1 hmgcs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HMGCS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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