Rabbit anti-Human hnRPD Polyclonal Antibody | anti-hnRPD antibody

hnRPD (Ab-83) Antibody

Cat. Num. AAA307764

• Gene Names: HNRNPD; P37; AUF1; AUF1A; HNRPD; hnRNPD0
• Reactivity: Human
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: hnRPD, Antibody; hnRPD (Ab-83) Antibody; ARE element RNA-binding protein AUF1; AU-rich element RNA-binding protein 1; AUF1; HNRPD; Heterogeneous nuclear ribonucleoprotein D; anti-hnRPD antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total hnRPD protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 287

• Applicable Applications for anti-hnRPD antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen Type: Peptide
• Immunogen Description: Synthesized non-phosphopeptide derived from human hnRPD around the phosphorylation site of serine 83 (N-S-S(p)-P-R).
• Target Name: hnRPD
• Preparation and Storage: Store at -20 degree C

IF (Immunofluorescence)

(Immunofluorescence analysis of HeLa cells, using hnRPD (Ab-83) antibody.)

IHC (Immunohiostchemistry)

(Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using hnRPD (Ab-83) antibody.)

WB (Western Blot)

(Western blot analysis of extracts from 293, JK, 3T3 and colo cells, using hnRPD (Ab-83) antibody.)

Related Product Information for anti-hnRPD antibody

Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Product Categories/Family for anti-hnRPD antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 51477708
• NCBI GeneID: 3184
• NCBI Accession #: NP_001003810.1
• NCBI GenBank Nucleotide #: NM_001003810.1
• UniProt Accession #: Q14103; P07029; Q01858; Q14100; Q14101; Q14102; Q4W5A1; Q9UCE8; Q9UCE9; A8K9J2
• Molecular Weight: 30,672 Da
• NCBI Official Full Name: heterogeneous nuclear ribonucleoprotein D0 isoform d
• NCBI Official Synonym Full Names: heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
• NCBI Official Symbol: HNRNPD
• NCBI Official Synonym Symbols: P37; AUF1; AUF1A; HNRPD; hnRNPD0
• NCBI Protein Information: heterogeneous nuclear ribonucleoprotein D0
• UniProt Protein Name: Heterogeneous nuclear ribonucleoprotein D0
• UniProt Gene Name: HNRNPD
• UniProt Synonym Gene Names: AUF1; HNRPD; hnRNP D0
• UniProt Entry Name: HNRPD_HUMAN