IHC (Immunohiostchemistry)
(Anti-HSD11B1 (AAA45695) antibody, IHC(P)IHC(P): Human Lung Cancer Tissue)
Rabbit HSD11B1 Polyclonal Antibody | anti-HSD11B1 antibody
Anti-HSD11B1 antibody
Gene Names
HSD11B1; HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Western Blot
Purity
Immunogen affinity purified.
Synonyms
HSD11B1, Antibody; Anti-HSD11B1 antibody; Corticosteroid 11-beta-dehydrogenase isozyme 1; hydroxysteroid(11-beta) dehydrogenase 1; 11 beta HSD 1 antibody; 11 beta HSD1 antibody; 11 beta hydroxysteroid dehydrogenase 1 antibody; 11 DH antibody; 11-beta hydroxysteroid dehydrogenase, type 1 antibody; 11-beta-HSD1 antibody; 11-beta-hydroxysteroid dehydrogenase 1 antibody; 11-DH antibody; 11DH antibody; Corticosteroid 11 beta dehydrogenase isozyme 1 antibody; Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody; CORTRD2 antibody; DHI1_HUMAN antibody; HDL antibody; HSD 11 antibody; HSD11 antibody; HSD11B antibody; HSD11B1 antibody; HSD11L antibody; Hydroxysteroid(11 beta) dehydrogenase 1 antibody; Hydroxysteroid(11 beta) dehydrogenase antibody; MGC13539 antibody; SDR26C1 antibody; short chain dehydrogenase/reductase family 26C, member 1 antibody; anti-HSD11B1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
292
Applicable Applications for anti-HSD11B1 antibody
IHC (Immunohistochemistry), WB (Western Blot)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human HSD11B1 (16-33aa MAYYYYSANEEFRPEMLQ), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
IHC (Immunohiostchemistry)
(Anti-HSD11B1 (AAA45695) antibody, IHC(P)IHC(P): Human Lung Cancer Tissue)
IHC (Immunohiostchemistry)
(Anti-HSD11B1 (AAA45695) antibody, IHC(P)IHC(P): Human Lung Cancer Tissue)
WB (Western Blot)
(Anti-HSD11B1 (AAA45695) antibody, Western blottingAll lanes: All lanes: Anti HSD11B1 (AAA45695) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Testis Tissue Lysate at 50ugLane 3: SMMC Whole Cell Lysate at 40ugLane 4: RAJI Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 32KDObserved bind size: 32KD)
WB (Western Blot)
(Anti-HSD11B1 (AAA45695) antibody, Western blottingAll lanes: All lanes: Anti HSD11B1 (AAA45695) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Testis Tissue Lysate at 50ugLane 3: SMMC Whole Cell Lysate at 40ugLane 4: RAJI Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 32KDObserved bind size: 32KD)
Related Product Information for anti-HSD11B1 antibody
Description: Rabbit IgG polyclonal antibody for Corticosteroid 11-beta-dehydrogenase isozyme 1(HSD11B1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: 11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al.(1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al.(2000) mapped the HSD11B1 gene to 1q32-q41.
Background: 11beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. Tannin et al.(1991) localized the HSD11B1 gene to chromosome 1. The localization was confirmed by isolating the gene from a chromosome 1-specific library using the cDNA as a probe. Schutte et al.(2000) mapped the HSD11B1 gene to 1q32-q41.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
32,401 Da
NCBI Official Full Name
Corticosteroid 11-beta-dehydrogenase isozyme 1
NCBI Official Synonym Full Names
hydroxysteroid (11-beta) dehydrogenase 1
NCBI Official Symbol
HSD11B1
NCBI Official Synonym Symbols
HDL; 11-DH; HSD11; HSD11B; HSD11L; CORTRD2; SDR26C1; 11-beta-HSD1
NCBI Protein Information
corticosteroid 11-beta-dehydrogenase isozyme 1; short chain dehydrogenase/reductase family 26C, member 1
UniProt Protein Name
Corticosteroid 11-beta-dehydrogenase isozyme 1
UniProt Gene Name
HSD11B1
UniProt Synonym Gene Names
HSD11; HSD11L; 11-DH; 11-beta-HSD1
UniProt Entry Name
DHI1_HUMAN
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Product Notes
The HSD11B1 hsd11b1 (Catalog #AAA45695) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-HSD11B1 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HSD11B1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot). Researchers should empirically determine the suitability of the HSD11B1 hsd11b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSD11B1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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