IHC (Immunohiostchemistry)
(HSPC142 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HSPC142 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit HSPC142 Polyclonal Antibody | anti-BABAM1 antibody
HSPC142 Antibody (N-term)
Gene Names
BABAM1; NBA1; HSPC142; MERIT40; C19orf62
Reactivity
Human (Predicted Reactivity: Bovine, Zebrafish)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
HSPC142, Antibody; HSPC142 Antibody (N-term); BRISC and BRCA1-A complex member 1; Mediator of RAP80 interactions and targeting subunit of 40 kDa; New component of the BRCA1-A complex; BABAM1; C19orf62; MERIT40; NBA1; anti-BABAM1 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine, Zebrafish)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
9-37
Sequence Length
171
Applicable Applications for anti-BABAM1 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(HSPC142 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HSPC142 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(HSPC142 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the HSPC142 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(HSPC142 Antibody (N-term) western blot analysis in T47D cell line lysates (15ug/lane).This demonstrates the HSPC142 antibody detected the HSPC142 protein (arrow).)
WB (Western Blot)
(HSPC142 Antibody (N-term) western blot analysis in T47D cell line lysates (15ug/lane).This demonstrates the HSPC142 antibody detected the HSPC142 protein (arrow).)
Related Product Information for anti-BABAM1 antibody
HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component
References
Solyom, S., et al. Breast Cancer Res. Treat. 120(1):165-168(2010)
Cooper, E.M., et al. EMBO J. 28(6):621-631(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Cooper, E.M., et al. EMBO J. 28(6):621-631(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
36560
NCBI Official Full Name
BRISC and BRCA1-A complex member 1 isoform 1
NCBI Official Synonym Full Names
BRISC and BRCA1 A complex member 1
NCBI Official Symbol
BABAM1
NCBI Official Synonym Symbols
NBA1; HSPC142; MERIT40; C19orf62
NCBI Protein Information
BRISC and BRCA1-A complex member 1
UniProt Protein Name
BRISC and BRCA1-A complex member 1
UniProt Gene Name
BABAM1
UniProt Synonym Gene Names
C19orf62; MERIT40; NBA1
UniProt Entry Name
BABA1_HUMAN
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Product Notes
The BABAM1 babam1 (Catalog #AAA285005) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 9-37. The HSPC142 Antibody (N-term) reacts with Human (Predicted Reactivity: Bovine, Zebrafish) and may cross-react with other species as described in the data sheet. AAA Biotech's HSPC142 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the BABAM1 babam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSPC142, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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