Rabbit anti-Human HSPG2 Polyclonal Antibody | anti-HSPG2 antibody

Anti-HSPG2 Antibody

Cat. Num. AAA46296

• Gene Names: HSPG2; PLC; SJA; SJS; HSPG; SJS1; PRCAN
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunogen affinity purified.
• Synonyms: HSPG2, Antibody; Anti-HSPG2 Antibody; Basement membrane-specific heparan sulfate proteoglycan core protein; Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin (domain V region); Heparan Sulfate Proteoglycan; Heparan sulfate proteoglycan of basement membrane; HSPG 2; HSPG; Hspg2; LG3 peptide; Perlecan; PGBM_HUMAN; PLC; Schwartz Jampel syndrome 1 (chondrodystrophic myotonia); SJA; SJS; SJS1; heparan sulfate proteoglycan 2; anti-HSPG2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins.
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized; Contains 5mg BSA, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.

• Applicable Applications for anti-HSPG2 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: E.coli-derived human HSPG2 recombinant protein (Position: F524-K701). ; Human HSPG2 shares 86% amino acid (aa) sequence identity with mouse HSPG2.
• Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20°C for one year. After reconstitution, at 4°C for one month. ; It can also be aliquoted and stored frozen at -20°C for a longer time. ; Avoid repeated freezing and thawing.

IHC (Immunohiostchemistry)

(Anti-HSPG2 Picoband antibody, AAA46296IHC(P): Human Lung Cancer Tissue)

WB (Western Blot)

(Anti-HSPG2 Picoband antibody, AAA46296, Western blottingAll lanes: Anti HSPG2 (AAA46296) at 0.5ug/mlWB: Recombinant Human HSPG2 Protein 0.5ngPredicted bind size: 69KDObserved bind size: 69KD)

Related Product Information for anti-HSPG2 antibody

Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

References

1. Arikawa-Hirasawa E, Le AH, Nishino I, Nonaka I, Ho NC, Francomano CA et al. (May 2002). 2. Iozzo RV (1994). "Perlecan: a gem of a proteoglycan". Matrix Biol. 14 (3): 203-8. 3. Kallunki P, Eddy RL, Byers MG, Kestilä M, Shows TB, Tryggvason K (October 1991). "Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism". Genomics 11 (2): 389-96.

NCBI and Uniprot Product Information

• NCBI GI #: 629266065
• NCBI GeneID: 3339
• NCBI Accession #: NP_001278789.1
• NCBI GenBank Nucleotide #: NM_001291860.1
• UniProt Accession #: P98160; Q16287; Q5SZI3; Q9H3V5
• NCBI Official Full Name: basement membrane-specific heparan sulfate proteoglycan core protein isoform a
• NCBI Official Synonym Full Names: heparan sulfate proteoglycan 2
• NCBI Official Symbol: HSPG2
• NCBI Official Synonym Symbols: PLC; SJA; SJS; HSPG; SJS1; PRCAN
• NCBI Protein Information: basement membrane-specific heparan sulfate proteoglycan core protein
• UniProt Protein Name: Basement membrane-specific heparan sulfate proteoglycan core protein
• UniProt Gene Name: HSPG2
• UniProt Synonym Gene Names: HSPG; PLC
• UniProt Entry Name: PGBM_HUMAN