IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human skin tissue using AAA119212 at dilution 1:100)
Rabbit anti-Human Hydroperoxide isomerase ALOXE3 Polyclonal Antibody | anti-ALOXE3 antibody
Rabbit anti-human Hydroperoxide isomerase ALOXE3 polyclonal Antibody(ALOXE3)
Gene Names
ALOXE3; ARCI3; E-LOX; eLOX3; eLOX-3
Reactivity
Human
Applications
Immunohistochemistry, ELISA
Purity
Antigen Affinity Purified
Synonyms
Hydroperoxide isomerase ALOXE3, Antibody; Rabbit anti-human Hydroperoxide isomerase ALOXE3 polyclonal Antibody(ALOXE3); Epidermis-type lipoxygenase 3; Epidermal LOX-3; e-LOX-3; eLOX-3; Hydroperoxy icosatetraenoate dehydratase; ALOXE3; anti-ALOXE3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Sequence Length
843
Applicable Applications for anti-ALOXE3 antibody
IHC (Immunohistochemistry), ELISA
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Hydroperoxide isomerase ALOXE3 protein (1-280aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133273 / sc-133275
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human skin tissue using AAA119212 at dilution 1:100)
IHC (Immunohiostchemistry)
(Immunohistochemistry of paraffin-embedded human skin tissue using AAA119212 at dilution 1:100)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human breast cancer using AAA119212 at dilution 1:100)
IHC (Immunohistochemistry)
(Immunohistochemistry of paraffin-embedded human breast cancer using AAA119212 at dilution 1:100)
Related Product Information for anti-ALOXE3 antibody
Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
95,186 Da
NCBI Official Full Name
hydroperoxide isomerase ALOXE3 isoform 1
NCBI Official Synonym Full Names
arachidonate lipoxygenase 3
NCBI Official Symbol
ALOXE3
NCBI Official Synonym Symbols
ARCI3; E-LOX; eLOX3; eLOX-3
NCBI Protein Information
hydroperoxide isomerase ALOXE3
UniProt Protein Name
Hydroperoxide isomerase ALOXE3
UniProt Gene Name
ALOXE3
UniProt Synonym Gene Names
Epidermal LOX-3; e-LOX-3; eLOX-3
UniProt Entry Name
LOXE3_HUMAN
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Product Notes
The ALOXE3 aloxe3 (Catalog #AAA119212) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Hydroperoxide isomerase ALOXE3 polyclonal Antibody(ALOXE3) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Hydroperoxide isomerase ALOXE3 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the ALOXE3 aloxe3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hydroperoxide isomerase ALOXE3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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