WB (Western Blot)
(Western Blot analysis of NIH-3T3 cells using IGF-IR Polyclonal Antibody at dilution of 1:500.)
Rabbit IGF-IR Polyclonal Antibody | anti-IGF-IR antibody
IGF-IR Polyclonal Antibody
Gene Names
IGF1R; IGFR; CD221; IGFIR; JTK13
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity purification
Synonyms
IGF-IR, Antibody; IGF-IR Polyclonal Antibody; IGF1R,Insulin-like growth factor 1 receptor,Insulinlike growth factor I receptor,IGF-I receptor,CD antigen CD221; anti-IGF-IR antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity purification
Form/Format
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH 7.4
Applicable Applications for anti-IGF-IR antibody
ELISA, WB (Western Blot)
Immunogen
Synthesized peptide derived from human IGF-IR around the non-phosphorylation site of Y1165/Y1166.
Calculated MW
155 kDa
Observed MW
155 kDa
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
WB (Western Blot)
(Western Blot analysis of NIH-3T3 cells using IGF-IR Polyclonal Antibody at dilution of 1:500.)
WB (Western Blot)
(Western Blot analysis of NIH-3T3 cells using IGF-IR Polyclonal Antibody at dilution of 1:500.)
Related Product Information for anti-IGF-IR antibody
Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulinlike rowth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades,thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine-binding (PTB) domains of Insulin receptor substrates (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into ? and ? subunits. The human IGFIIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid ransmembrane protein.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
insulin-like growth factor 1 receptor isoform 2
NCBI Official Synonym Full Names
insulin like growth factor 1 receptor
NCBI Official Symbol
IGF1R
NCBI Official Synonym Symbols
IGFR; CD221; IGFIR; JTK13
NCBI Protein Information
insulin-like growth factor 1 receptor
UniProt Protein Name
Insulin-like growth factor 1 receptor
UniProt Gene Name
IGF1R
UniProt Synonym Gene Names
IGF-I receptor
UniProt Entry Name
IGF1R_HUMAN
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Product Notes
The IGF-IR igf1r (Catalog #AAA171967) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IGF-IR Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IGF-IR can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the IGF-IR igf1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IGF-IR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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