Rabbit anti-Human, Mouse IKAP Polyclonal Antibody | anti-IKAP antibody

IKAP Antibody

Cat. Num. AAA305653

• Gene Names: IKBKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1
• Reactivity: Human, Mouse
• Applications: Immunocytochemistry, Western Blot, ELISA
• Purity: Affinity chromatography purified via peptide column
• Synonyms: IKAP, Antibody; IKAP Antibody; IKK complex-associated protein, IKBKAP; anti-IKAP antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 1332

• Applicable Applications for anti-IKAP antibody: ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 16 amino acid peptide from near the carboxy terminus of human IKAP.
• Target Name: IKAP
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ICC (Immunocytochemistry)

(Immunocytochemistry of IKAP in A-20 cells with IKAP antibody at 1 ug/mL.)

WB (Western Blot)

(Western blot analysis of IKAP in A-20 cell lysate with IKAP antibody at in (A) 0.5, and (B) 1 ug/mL.)

Related Product Information for anti-IKAP antibody

IKAP was initially identified as a scaffold protein of the IkB kinase complex that could bind to IKKa, IKKb, NF-kB, and the NF-kB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation. More recently, it was shown that IKAP associates with c-Jun N-terminal kinase (JNK) and could specifically enhance JNK activation induced by the upstream JNK activators MEKK1 and ASK1, indicating another possible cause for FD. At least two isoforms of IKAP are known two exist.

Product Categories/Family for anti-IKAP antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 3757822
• NCBI GeneID: 8518
• Molecular Weight: 150,254 Da
• NCBI Official Full Name: IkappaB kinase complex associated protein
• NCBI Official Synonym Full Names: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
• NCBI Official Symbol: IKBKAP
• NCBI Official Synonym Symbols: FD; DYS; ELP1; IKAP; IKI3; TOT1
• NCBI Protein Information: elongator complex protein 1
• UniProt Protein Name: Elongator complex protein 1
• UniProt Gene Name: IKBKAP
• UniProt Synonym Gene Names: ELP1; IKAP; ELP1; IKK complex-associated protein
• UniProt Entry Name: ELP1_HUMAN