Rabbit anti-Human IKK alpha Polyclonal Antibody | anti-CHUK antibody

IKK alpha Antibody

Cat. Num. AAA39891

• Gene Names: CHUK; IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha
• Reactivity: Human
• Applications: Immunofluorescence, Immunocytochemistry, Western Blot, ELISA
• Purity: IKK alpha Antibody is affinity chromatography purified via peptide column.
• Synonyms: IKK alpha, Antibody; IKK alpha Antibody; IKK alpha; IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase alpha; conserved helix-loop-helix ubiquitous kinase; anti-CHUK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This polyclonal antibody has no cross response to IKKb or IKKy.
• Purity/Purification: IKK alpha Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Sequence Length: 2273

• Applicable Applications for anti-CHUK antibody: IF (Immunofluorescence), ICC (Immunocytochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: IKK alpha antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK alpha.
• Buffer: IKK alpha Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: IKK alpha antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of IKKa in HeLa cells with IKKa antibody at 2 μg/mL.)

ICC (Immunocytochemistry)

(Immunocytochemistry of IKK alpha in HeLa cells with IKK alpha antibody at 10 μg/mL.)

WB (Western Blot)

(Western blot analysis of IKK alpha in HeLa cell lysate with IKK alpha antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Related Product Information for anti-CHUK antibody

IKK alpha Antibody: Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and bacteria product LPS. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ). IKKα and IKKβ interact with each other and both are essential for the NF-κB activation. IKKα specifically phosphorylates IκB-alpha. IKKα is expressed in a variety of human tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 2327068
• NCBI GeneID: 1147
• UniProt Accession #: O15111; O14666; Q13132; Q5W0I4; Q92467
• Molecular Weight: 85 kDa
• NCBI Official Full Name: Homo sapiens IkB kinase alpha subunit (IKK alpha) mRNA, complete cds
• NCBI Official Synonym Full Names: conserved helix-loop-helix ubiquitous kinase
• NCBI Official Symbol: CHUK
• NCBI Official Synonym Symbols: IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha
• NCBI Protein Information: inhibitor of nuclear factor kappa-B kinase subunit alpha; TCF-16; IKK-a kinase; I-kappa-B kinase 1; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; Nuclear factor NFkappaB inhibitor kinase alpha
• UniProt Protein Name: Inhibitor of nuclear factor kappa-B kinase subunit alpha
• UniProt Gene Name: CHUK
• UniProt Synonym Gene Names: IKKA; TCF16; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; IKK1; NFKBIKA; TCF-16
• UniProt Entry Name: IKKA_HUMAN