Rabbit anti-Human IL-37 Polyclonal Antibody | anti-IL37 antibody

IL-37 Antibody

Cat. Num. AAA40493

• Gene Names: IL37; FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
• Reactivity: Human
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: IL-37 Antibody is affinity chromatography purified via peptide column.
• Synonyms: IL-37, Antibody; IL-37 Antibody; IL-37 Antibody : FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA); Interleukin-37; FIL1 zeta; interleukin 37; anti-IL37 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist; this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.
• Purity/Purification: IL-37 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 218

• Applicable Applications for anti-IL37 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: IL-37 antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.
• Buffer: IL-37 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: IL-37 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

IF (Immunofluorescence)

(Immunofluorescence of IL-12A in human kidney tissue with IL-12A antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of IL-12A in human kidney tissue with IL-12A antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of IL-37 in human lung tissue lysate with IL-37 antibody at 1 μg/ml in (A) the presence and (B) the absence of blocking peptide.)

Related Product Information for anti-IL37 antibody

Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1). It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1). IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3).

NCBI and Uniprot Product Information

• NCBI GI #: 20127524
• NCBI GeneID: 27178
• NCBI Accession #: NP_055254
• NCBI GenBank Nucleotide #: NM_014439.3
• UniProt Accession #: Q9NZH6; Q56AP9; Q8TD04; Q8TD05; Q9HBF2; Q9HBF3; Q9UHA6; B5BU97
• Molecular Weight: Predicted: 24 kDa; ; Observed: 23kDa
• NCBI Official Full Name: interleukin-37 isoform 1
• NCBI Official Synonym Full Names: interleukin 37
• NCBI Official Symbol: IL37
• NCBI Official Synonym Symbols: FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
• NCBI Protein Information: interleukin-37; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b)
• UniProt Protein Name: Interleukin-37
• UniProt Gene Name: IL37
• UniProt Synonym Gene Names: FIL1Z; IL1F7; IL1H4; IL1RP1; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; IL-37
• UniProt Entry Name: IL37_HUMAN