WB (Western Blot)
(Western Blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4 degree C over night.)
Rabbit IL1RAP Polyclonal Antibody | anti-IL1RAP antibody
IL1RAP Antibody
Gene Names
IL1RAP; IL1R3; C3orf13; IL-1RAcP
Reactivity
Human; Rat; Mouse
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
IL1RAP, Antibody; IL1RAP Antibody; C3orf13; IL-1RAcP; IL1R3; anti-IL1RAP antibody
Host
Rabbit
Reactivity
Human; Rat; Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody detects endogenous levels of IL1AP at Human/Mouse/Rat
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (varies by lot)
Applicable Applications for anti-IL1RAP antibody
WB (Western Blot)
Immunogen
Synthesized peptide derived from human IL1AP AA range: 213-263
Function
function: Mediates interleukin-1-dependent activation of NF-kappa-B. Isoform 1 is part of the membrane-bound form of the IL-1 receptor. Signaling involves formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. Isoform 2 modulates the response to interleukins by associating with soluble IL1R1 and enhancing interleukin-binding to the decoy receptor., induction: Phorbol ester treatment causes down-regulation of isoform 1 and induction of isoform 2., similarity:Belongs to the interleukin-1 receptor family.,similarity: Contains 1 TIR domain.,similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains, tissue specificity: Detected in liver, skin, placenta, thymus and lung.
Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
Expression
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).
Preparation and Storage
15°C to -25°C/1 year(Do not lower than -25°C)
WB (Western Blot)
(Western Blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4 degree C over night.)
WB (Western Blot)
(Western Blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4 degree C over night.)
Related Product Information for anti-IL1RAP antibody
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
65kDa
NCBI Official Full Name
interleukin-1 receptor accessory protein isoform 1
NCBI Official Synonym Full Names
interleukin 1 receptor accessory protein
NCBI Official Symbol
IL1RAP
NCBI Official Synonym Symbols
IL1R3; C3orf13; IL-1RAcP
NCBI Protein Information
interleukin-1 receptor accessory protein
UniProt Protein Name
Interleukin-1 receptor accessory protein
UniProt Gene Name
IL1RAP
UniProt Synonym Gene Names
C3orf13; IL1R3; IL-1 receptor accessory protein; IL-1RAcP; IL-1R-3; IL-1R3
Similar Products
Product Notes
The IL1RAP il1rap (Catalog #AAA266863) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IL1RAP Antibody reacts with Human; Rat; Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's IL1RAP can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the IL1RAP il1rap for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL1RAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.