FCM/FACS (Flow Cytometry)
(IMPDH2 Antibody (Center) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Rabbit IMPDH2 Polyclonal Antibody | anti-IMPDH2 antibody
IMPDH2 Antibody (Center)
Gene Names
IMPDH2; IMPD2; IMPDH-II
Reactivity
Human (Predicted Reactivity: Bovine, Mouse, Rat, Hamster, Zebrafish)
Applications
Immunohistochemistry, Western Blot, ELISA, Flow Cytometry, Functional Assay
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
IMPDH2, Antibody; IMPDH2 Antibody (Center); Inosine-5'-monophosphate dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMP dehydrogenase 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPD 2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH 2 {ECO:0000255|HAMAP-Rule:MF_03156}; 111205 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPDH-II; IMPDH2 {ECO:0000255|HAMAP-Rule:MF_03156}; IMPD2; anti-IMPDH2 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Bovine, Mouse, Rat, Hamster, Zebrafish)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This IMPDH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-210 amino acids from the Central region of human IMPDH2.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (varies by lot)
Sequence Positions
180-210
Sequence Length
514
Applicable Applications for anti-IMPDH2 antibody
IHC (Immunohistochemistry), WB (Western Blot), ELISA, FCM/FACS (Flow Cytometry)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
FCM/FACS (Flow Cytometry)
(IMPDH2 Antibody (Center) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
FCM/FACS (Flow Cytometry)
(IMPDH2 Antibody (Center) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
IHC (Immunohiostchemistry)
(IMPDH2 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IMPDH2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(IMPDH2 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded human Lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IMPDH2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(Western blot analysis of IMPDH2 Antibody (Center) in NCI-H460,Hela,MCF7,A2058 cell line lysates(35ug/lane). IMPDH2 (arrow) was detected using the purified Pab.)
WB (Western Blot)
(Western blot analysis of IMPDH2 Antibody (Center) in NCI-H460,Hela,MCF7,A2058 cell line lysates(35ug/lane). IMPDH2 (arrow) was detected using the purified Pab.)
Related Product Information for anti-IMPDH2 antibody
IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. Its gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Product Categories/Family for anti-IMPDH2 antibody
References
Sombogaard,F., Pharmacogenet. Genomics 19 (8), 626-634 (2009)
Mohamed,M.F., Genet. Test. 12 (4), 513-516 (2008)
Mohamed,M.F., Genet. Test. 12 (4), 513-516 (2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55805
NCBI Official Full Name
inosine-5'-monophosphate dehydrogenase 2
NCBI Official Synonym Full Names
IMP (inosine 5'-monophosphate) dehydrogenase 2
NCBI Official Symbol
IMPDH2
NCBI Official Synonym Symbols
IMPD2; IMPDH-II
NCBI Protein Information
inosine-5'-monophosphate dehydrogenase 2
UniProt Protein Name
Inosine-5'-monophosphate dehydrogenase 2
UniProt Gene Name
IMPDH2
UniProt Synonym Gene Names
IMP dehydrogenase 2; IMPD 2; IMPDH 2
UniProt Entry Name
IMDH2_HUMAN
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Product Notes
The IMPDH2 impdh2 (Catalog #AAA289491) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 180-210. The IMPDH2 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat, Hamster, Zebrafish) and may cross-react with other species as described in the data sheet. AAA Biotech's IMPDH2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), ELISA, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the IMPDH2 impdh2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IMPDH2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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