Rabbit IPR1 Polyclonal Antibody | anti-SP110 antibody

IPR1 Antibody

Cat. Num. AAA39456

• Gene Names: SP110; IPR1; VODI; IFI41; IFI75
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: IPR1 Antibody is affinity chromatography purified via peptide column.
• Synonyms: IPR1, Antibody; IPR1 Antibody; IPR1; VODI; IFI41; IFI75; Sp110 nuclear body protein; Speckled 110 kDa; SP110 nuclear body protein; anti-SP110 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: IPR1 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 549

• Applicable Applications for anti-SP110 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: IPR1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human IPR1.
• Buffer: IPR1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: IPR1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IF (Immunofluorescence)

(Immunofluorescence of IPR1 in Human Brain cells with IPR1 antibody at 50 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemical staining of human brain tissue using IPR1 antibody at 2.5 μg/mL.)

WB (Western Blot)

(Western blot analysis of IPR1 in Hela cell lysate with IPR1 antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.)

Related Product Information for anti-SP110 antibody

IPR1 Antibody: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

NCBI and Uniprot Product Information

• NCBI GI #: 190343008
• NCBI GeneID: 3431
• NCBI Accession #: NP_004501
• NCBI GenBank Nucleotide #: NM_004510.3
• UniProt Accession #: Q9HB58; Q14976; Q14977; Q53TG2; Q8WUZ6; Q9HCT8; B4DVI4; F5H1M1
• Molecular Weight: 62,603 Da
• NCBI Official Full Name: sp110 nuclear body protein isoform b
• NCBI Official Synonym Full Names: SP110 nuclear body protein
• NCBI Official Symbol: SP110
• NCBI Official Synonym Symbols: IPR1; VODI; IFI41; IFI75
• NCBI Protein Information: sp110 nuclear body protein; speckled 110 kDa; phosphoprotein 41; phosphoprotein 75; interferon-induced protein 41/75; transcriptional coactivator Sp110; interferon-induced protein 41, 30kD; interferon-induced protein 75, 52kD
• UniProt Protein Name: Sp110 nuclear body protein
• UniProt Gene Name: SP110
• UniProt Entry Name: SP110_HUMAN