Rabbit JIP-1 Polyclonal Antibody | anti-JIP-1 antibody

JIP-1 Polyclonal Antibody

Cat. Num. AAA295106

• Gene Names: MAPK8IP1; IB1; JIP1; JIP-1; PRKM8IP
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot
• Synonyms: JIP-1, Antibody; JIP-1 Polyclonal Antibody; MAPK8IP1; IB1; JIP1; PRKM8IP; C-Jun-amino-terminal kinase-interacting protein 1; JIP-1; JNK-interacting protein 1; Islet-brain 1; IB-1; JNK MAP kinase scaffold protein 1; Mitogen-activated protein kinase 8-interacting protein 1; anti-JIP-1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal

• Applicable Applications for anti-JIP-1 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.)

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.)

Related Product Information for anti-JIP-1 antibody

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK- regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Acts as a scaffold protein that coordinates with SH3RF1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the activation of MAPK8/JNK1 and differentiation of CD8 (+) T-cells.

NCBI and Uniprot Product Information

• NCBI GI #: 4885433
• NCBI GeneID: 9479
• NCBI Accession #: NP_005447.1
• NCBI GenBank Nucleotide #: NM_005456.3
• UniProt Accession #: Q9UQF2; O43407; D3DQP4
• Molecular Weight: 77,524 Da
• NCBI Official Full Name: C-Jun-amino-terminal kinase-interacting protein 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase 8 interacting protein 1
• NCBI Official Symbol: MAPK8IP1
• NCBI Official Synonym Symbols: IB1; JIP1; JIP-1; PRKM8IP
• NCBI Protein Information: C-Jun-amino-terminal kinase-interacting protein 1; IB-1; islet-brain 1; JNK-interacting protein 1; PRKM8 interacting protein; JNK MAP kinase scaffold protein 1
• UniProt Protein Name: C-Jun-amino-terminal kinase-interacting protein 1
• UniProt Gene Name: MAPK8IP1
• UniProt Synonym Gene Names: IB1; JIP1; PRKM8IP; JIP-1; JNK-interacting protein 1; IB-1
• UniProt Entry Name: JIP1_HUMAN