WB (Western Blot)
(KCND3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCND3 antibody detected the KCND3 protein (arrow).)
Rabbit KCND3 Polyclonal Antibody | anti-KCND3 antibody
KCND3 Antibody (N-term)
Gene Names
KCND3; KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Applications
ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
KCND3, Antibody; KCND3 Antibody (N-term); Potassium voltage-gated channel subfamily D member 3; Voltage-gated potassium channel subunit Kv43; KCND3; anti-KCND3 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse, Rat)
Clonality
Polyclonal
Isotype
IgG
Specificity
This KCND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-41 amino acids from the N-terminal region of human KCND3.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Sequence Positions
13-41
Sequence Length
636
Applicable Applications for anti-KCND3 antibody
ELISA, WB (Western Blot)
Function
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
Cellular Location
Cell membrane {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62897}.
Note: Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression {ECO:0000250|UniProtKB:Q62897}
Note: Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression {ECO:0000250|UniProtKB:Q62897}
Tissue Location
Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas
Preparation and Storage
Store at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
WB (Western Blot)
(KCND3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCND3 antibody detected the KCND3 protein (arrow).)
WB (Western Blot)
(KCND3 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCND3 antibody detected the KCND3 protein (arrow).)
Related Product Information for anti-KCND3 antibody
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq].
Product Categories/Family for anti-KCND3 antibody
References
Lundby, A., et al. Br. J. Pharmacol. 160(8):2028-2044(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Liang, P., et al. Biophys. J. 98(12):2867-2876(2010)
Cotella, D., et al. Pflugers Arch. 460(1):87-97(2010)
Tan, X.Q., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(6):509-513(2009)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Liang, P., et al. Biophys. J. 98(12):2867-2876(2010)
Cotella, D., et al. Pflugers Arch. 460(1):87-97(2010)
Tan, X.Q., et al. Zhonghua Xin Xue Guan Bing Za Zhi 37(6):509-513(2009)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated MW: 73451
NCBI Official Full Name
potassium voltage-gated channel subfamily D member 3 isoform 1
NCBI Official Synonym Full Names
potassium channel, voltage gated Shal related subfamily D, member 3
NCBI Official Symbol
KCND3
NCBI Official Synonym Symbols
KV4.3; SCA19; SCA22; BRGDA9; KCND3L; KCND3S; KSHIVB
NCBI Protein Information
potassium voltage-gated channel subfamily D member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily D member 3
UniProt Gene Name
KCND3
UniProt Entry Name
KCND3_HUMAN
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Product Notes
The KCND3 kcnd3 (Catalog #AAA284863) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 13-41. The KCND3 Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's KCND3 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the KCND3 kcnd3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCND3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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