WB (Western Blot)
(Western blot analysis of extracts from mouse muscle, using KCNS3 Antibody.)
Rabbit anti-Human, Mouse KCNS3 Polyclonal Antibody | anti-KCNS3 antibody
KCNS3 Antibody
Gene Names
KCNS3; KV9.3
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
KCNS3, Antibody; KCNS3 Antibody; Delayed rectifier K(+) channel alpha subunit 3; Delayed rectifier K+ channel alpha subunit 3; Delayed-rectifier K(+) channel alpha subunit 3; KCNS 3; Kcns3; KCNS3_HUMAN; KV 9.3; KV9.3; MGC9481; Potassium voltage gated channel delayed rectifier protein S3; Potassium voltage gated channel delayed rectifier subfamily S member 3; Potassium voltage gated channel subfamily S member 3; Potassium voltage-gated channel subfamily S member 3; Shab related delayed rectifier K+ channel alpha subunit 3; Voltage gated potassium channel subunit Kv9.3; Voltage-gated potassium channel subunit Kv9.3; anti-KCNS3 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
KCNS3 antibody detects endogenous levels of total KCNS3
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
491
Applicable Applications for anti-KCNS3 antibody
ELISA, WB (Western Blot)
Immunogen
A synthesized peptide derived from human KCNS3
Subcellular Location
Cell Membrane. May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.
Tissue Specificity
Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328).
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Similarity
Pig (100%), Bovine (100%), Horse (90%), Sheep (100%), Rabbit (100%), Dog (90%), Chicken (80%)
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
WB (Western Blot)
(Western blot analysis of extracts from mouse muscle, using KCNS3 Antibody.)
WB (Western Blot)
(Western blot analysis of extracts from mouse muscle, using KCNS3 Antibody.)
WB (Western Blot)
(Western blot analysis of KCNS3 using LOVO whole cell lysates)
WB (Western Blot)
(Western blot analysis of KCNS3 using LOVO whole cell lysates)
Related Product Information for anti-KCNS3 antibody
Function: Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:10484328). Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).
Subunit Structure: Heterotetramer with KCNB1 (PubMed:10484328). Does not form homomultimers (PubMed:10484328).
Similarity: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
Subunit Structure: Heterotetramer with KCNB1 (PubMed:10484328). Does not form homomultimers (PubMed:10484328).
Similarity: The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region. Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 56 kDa
Predicted: 57 kDa
Predicted: 57 kDa
NCBI Official Full Name
potassium voltage-gated channel subfamily S member 3
NCBI Official Synonym Full Names
potassium voltage-gated channel modifier subfamily S member 3
NCBI Official Symbol
KCNS3
NCBI Official Synonym Symbols
KV9.3
NCBI Protein Information
potassium voltage-gated channel subfamily S member 3
UniProt Protein Name
Potassium voltage-gated channel subfamily S member 3
UniProt Gene Name
KCNS3
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Product Notes
The KCNS3 kcns3 (Catalog #AAA328106) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KCNS3 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's KCNS3 can be used in a range of immunoassay formats including, but not limited to, ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the KCNS3 kcns3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KCNS3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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