IHC (Immunohiostchemistry)
(KDELR2 Antibody (C-term) (AAA284850)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KDELR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rabbit KDELR2 Polyclonal Antibody | anti-KDELR2 antibody
KDELR2 Antibody (C-term)
Gene Names
KDELR2; ELP-1; ERD2.2
Reactivity
Human (Predicted Reactivity: Xenopus, Bovine, Mouse, Rat)
Applications
Immunohistochemistry, ELISA, Western Blot
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
KDELR2, Antibody; KDELR2 Antibody (C-term); ER lumen protein-retaining receptor 2; ERD2-like protein 1; ELP-1; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; KDELR2; ERD22; anti-KDELR2 antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Xenopus, Bovine, Mouse, Rat)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This KDELR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human KDELR2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
183-211
Sequence Length
186
Applicable Applications for anti-KDELR2 antibody
IHC (Immunohistochemistry), ELISA, WB (Western Blot)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
IHC (Immunohiostchemistry)
(KDELR2 Antibody (C-term) (AAA284850)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KDELR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
IHC (Immunohiostchemistry)
(KDELR2 Antibody (C-term) (AAA284850)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KDELR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
WB (Western Blot)
(KDELR2 Antibody (C-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the KDELR2 antibody detected the KDELR2 protein (arrow).)
WB (Western Blot)
(KDELR2 Antibody (C-term) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the KDELR2 antibody detected the KDELR2 protein (arrow).)
Related Product Information for anti-KDELR2 antibody
Retention of resident soluble proteins in the lumen of the
endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a
pre-Golgi compartment. Sorting of these proteins is dependent on a
C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In
yeast, the sorting receptor encoded by a single gene, ERD2, is a
seven-transmembrane protein. Unlike yeast, several human homologs
of the ERD2 gene, constituting the KDEL receptor gene family, have
been described. KDELR2 was the second member of the family to be
identified, and it encodes a protein which is 83% identical to the
KDELR1 gene product. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. [provided by
RefSeq].
endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a
pre-Golgi compartment. Sorting of these proteins is dependent on a
C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In
yeast, the sorting receptor encoded by a single gene, ERD2, is a
seven-transmembrane protein. Unlike yeast, several human homologs
of the ERD2 gene, constituting the KDEL receptor gene family, have
been described. KDELR2 was the second member of the family to be
identified, and it encodes a protein which is 83% identical to the
KDELR1 gene product. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. [provided by
RefSeq].
Product Categories/Family for anti-KDELR2 antibody
References
van der Vlies, D., et al. Biochem. J. 366 (PT 3), 825-830 (2002) :
Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)
Lewis, M.J., et al. J. Mol. Biol. 226(4):913-916(1992)
Hsu, V.W., et al. Cell 69(4):625-635(1992)
Pelham, H.R. Cell Struct. Funct. 21(5):413-419(1996)
Lewis, M.J., et al. J. Mol. Biol. 226(4):913-916(1992)
Hsu, V.W., et al. Cell 69(4):625-635(1992)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24422
NCBI Official Full Name
ER lumen protein-retaining receptor 2 isoform 2
NCBI Official Synonym Full Names
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
NCBI Official Symbol
KDELR2
NCBI Official Synonym Symbols
ELP-1; ERD2.2
NCBI Protein Information
ER lumen protein-retaining receptor 2
UniProt Protein Name
ER lumen protein-retaining receptor 2
UniProt Gene Name
KDELR2
UniProt Synonym Gene Names
ERD2.2; ELP-1; KDEL receptor 2
UniProt Entry Name
ERD22_HUMAN
Similar Products
Product Notes
The KDELR2 kdelr2 (Catalog #AAA284850) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 183-211. The KDELR2 Antibody (C-term) reacts with Human (Predicted Reactivity: Xenopus, Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's KDELR2 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the KDELR2 kdelr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "KDELR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.