Rabbit KPNA2 Polyclonal Antibody | anti-KPNA2 antibody

KPNA2 Antibody

Cat. Num. AAA39220

• Gene Names: KPNA2; QIP2; RCH1; IPOA1; SRP1alpha
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: KPNA2 Antibody is affinity chromatography purified via peptide column.
• Synonyms: KPNA2, Antibody; KPNA2 Antibody; KPNA2; QIP2; RCH1; IPOA1; SRP1alpha; SRP1; Importin subunit alpha-1; Karyopherin subunit alpha-2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); anti-KPNA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: KPNA2 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 529

• Applicable Applications for anti-KPNA2 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: KPNA2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA2.
• Buffer: KPNA2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: KPNA2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

WB (Western Blot)

(Western blot analysis of KPNA2 expression in Daudi cell lysate with KPNA2 antibody at (A) 1 and (B) 2 μg/ml.)

IF (Immunofluorescence)

(Immunofluorescence of KPNA2 in human heart tissue with KPNA2 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of KPNA2 in human heart tissue with KPNA2 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 antibody at (A) 1 and (B) 2 μg/mL.)

Related Product Information for anti-KPNA2 antibody

KPNA2 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA2 is the alpha subunit 2 of karyopherin, which forms a complex with importin subunit beta-1 and functions as a cargo carrier that transports various complexes from cytoplasm into nucleus. It is ubiquitously expressed and contains an IBB/importin beta domain, ten Armadillo repeats that bind "cargo" and three intervening nuclear localization sequences (NLSs). It has recently been reported to play an important role in tumorigenesis and tumor progression.

NCBI and Uniprot Product Information

• NCBI GI #: 4504897
• NCBI GeneID: 3838
• NCBI Accession #: NP_002257
• NCBI GenBank Nucleotide #: NM_002266.2
• UniProt Accession #: P52292; Q53YE3; Q9BRU5; B9EJD6
• Molecular Weight: 57,862 Da
• NCBI Official Full Name: importin subunit alpha-1
• NCBI Official Synonym Full Names: karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
• NCBI Official Symbol: KPNA2
• NCBI Official Synonym Symbols: QIP2; RCH1; IPOA1; SRP1alpha
• NCBI Protein Information: importin subunit alpha-1; pendulin; SRP1-alpha; RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; RAG cohort protein 1; importin subunit alpha-2; karyopherin subunit alpha-2
• UniProt Protein Name: Importin subunit alpha-1
• UniProt Gene Name: KPNA2
• UniProt Synonym Gene Names: RCH1; SRP1
• UniProt Entry Name: IMA1_HUMAN