Rabbit anti-Human, Mouse LIN52 Polyclonal Antibody | anti-LIN52 antibody

Anti-LIN52 Antibody, Rabbit Polyclonal

Cat. Num. AAA254914

• Gene Names: LIN52; C14orf46; c14_5549
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: LIN52, Antibody; Anti-LIN52 Antibody, Rabbit Polyclonal; LIN52 Antibody, Rabbit PAb, Antigen Affinity Purified; Anti-C14orf46 Antibody; anti-LIN52 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human LIN52
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-LIN52 antibody: IHC (Immunohistochemistry)
• Immunogen: A synthetic peptide corresponding to the center region of the Human LIN52
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human LIN52, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

IHC (Immunohiostchemistry)

(Immunochemical staining LIN52 in mouse liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

IHC (Immunohistochemistry)

(Immunochemical staining LIN52 in human liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-LIN52 antibody

The MuvB complex of five proteins (LIN9, LIN37, LIN52, RBBP4, and LIN54), also known as LINC (LIN complex), is important for coordinated cell cycle gene expression. By participating in the formation of three distinct transcriptional regulatory complexes, including DREAM (DP, RB-like, E2F, and MuvB), MMB (Myb-MuvB), and FoxM1-MuvB, MuvB represents a unique regulator mediating either transcriptional activation (during S-G2 phases) or repression (during quiescence). The serine residue 28 of LIN52 is phosphorylated by DYRK1A, and point mutation of this residue or down regulation of DYRK1A (which phosphorylates LIN52) leads to disruption of DREAM complex assembly, which is needed for G(0) arrest. dlin52, the Drosophila orthologue of LIN52, is strongly conserved across various taxa from worms to human. dlin52 is reported to be present in a large protein complex containing important transcriptional regulators of cell proliferation and cell death like dE2F1, dMyb and dRbf.

References

Iness AN, et al. (2018) Muvb: A key to cell cycle control in ovarian cancer. Front Oncol 8 223.Bhaskar PK, et al. (2014) Dlin52 is crucial for de2f and drbf mediated transcriptional regulation of pro-apoptotic gene hid. Biochim Biophys Acta 1839 (9): 800-812.Bhaskar PK, et al. (2012) Dynamic pattern of expression of dlin52, a member of the myb/muvb complex, during drosophila development. Gene Expr Patterns 12 (1-2): 77-84.

NCBI and Uniprot Product Information

• NCBI GI #: 67003578
• NCBI GeneID: 91750
• NCBI Accession #: NP_001019845.1
• NCBI GenBank Nucleotide #: NM_001024674.2
• UniProt Accession #: Q52LA3
• Molecular Weight: 13,001 Da
• NCBI Official Full Name: protein lin-52 homolog
• NCBI Official Synonym Full Names: lin-52 DREAM MuvB core complex component
• NCBI Official Symbol: LIN52
• NCBI Official Synonym Symbols: C14orf46; c14_5549
• NCBI Protein Information: protein lin-52 homolog
• UniProt Protein Name: Protein lin-52 homolog
• UniProt Gene Name: LIN52
• UniProt Synonym Gene Names: C14orf46
• UniProt Entry Name: LIN52_HUMAN