ICC (Immunocytochemistry)
(Immunocytochemistry of LIS1 in Jurkat cells with LIS1 antibody at 2.5 ug/mL.)
Rabbit LIS1 Polyclonal Antibody | anti-LIS1 antibody
LIS1 Antibody
Gene Names
PAFAH1B1; MDS; LIS1; LIS2; MDCR; PAFAH
Reactivity
Human, Mouse, Rat
Applications
Immunocytochemistry, Western Blot, ELISA
Purity
Affinity chromatography purified via peptide column
Synonyms
LIS1, Antibody; LIS1 Antibody; Lissencephaly 1, platelet-activating factor acetylhydrolase, PAFAH; anti-LIS1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
410
Applicable Applications for anti-LIS1 antibody
ICC (Immunocytochemistry), WB (Western Blot), ELISA
Immunogen Type
Peptide
Immunogen Description
Raised against a 14 amino acid peptide from near the carboxy terminus of human LIS1.
Target Name
LIS1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
ICC (Immunocytochemistry)
(Immunocytochemistry of LIS1 in Jurkat cells with LIS1 antibody at 2.5 ug/mL.)
ICC (Immunocytochemistry)
(Immunocytochemistry of LIS1 in Jurkat cells with LIS1 antibody at 2.5 ug/mL.)
WB (Western Blot)
(Western blot analysis of LIS1 in HeLa cell lysate with LIS1 antibody at (A) 0.5 and (B) 1 ug/mL.)
WB (Western Blot)
(Western blot analysis of LIS1 in HeLa cell lysate with LIS1 antibody at (A) 0.5 and (B) 1 ug/mL.)
Related Product Information for anti-LIS1 antibody
Lissencephaly is a severe brain developmental disease characterized by the mislocalization of cortical neurons, a smooth cerebral surface, mental retardation, and seizures. Classical lissencephaly is caused by sporadic mutations in the LIS1 gene. While LIS1 is known to act in a pathway deactivating the lipid messenger platelet-activating factor, LIS1 forms a complex with Nudel and 14-3-3epsilon which is then transported from neuronal cell bodies through the actions of DISC1 and KIF5A, a microtubule-dependent directed motor protein kinesin. Decreased expression of LIS1 blocked neural stem cell division, morphogenesis, and motility, suggesting that LIS1 plays an important role in neuronal cell proliferation and localization in the developing brain. At least two isoforms of LIS1 are known to exist.
Product Categories/Family for anti-LIS1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16,869 Da
NCBI Official Full Name
platelet-activating factor acetylhydrolase IB subunit alpha
NCBI Official Synonym Full Names
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
NCBI Official Symbol
PAFAH1B1
NCBI Official Synonym Symbols
MDS; LIS1; LIS2; MDCR; PAFAH
NCBI Protein Information
platelet-activating factor acetylhydrolase IB subunit alpha
UniProt Protein Name
Platelet-activating factor acetylhydrolase IB subunit alpha
UniProt Gene Name
PAFAH1B1
UniProt Synonym Gene Names
LIS-1; PAF-AH 45 kDa subunit; PAFAH alpha
UniProt Entry Name
LIS1_HUMAN
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Product Notes
The LIS1 pafah1b1 (Catalog #AAA305368) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LIS1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LIS1 can be used in a range of immunoassay formats including, but not limited to, ICC (Immunocytochemistry), WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the LIS1 pafah1b1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LIS1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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