IHC (Immunohistochemisry)
(LRP2/Megalin Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit LRP2/Megalin Polyclonal Antibody | anti-LRP2 antibody
LRP2/Megalin Rabbit anti-Human Polyclonal Antibody
Gene Names
LRP2; DBS; GP330
Reactivity
Mouse, Rat, Human
Applications
Western Blot, Immunohistochemistry
Purity
Immunoaffinity chromatography
Synonyms
LRP2/Megalin, Antibody; LRP2/Megalin Rabbit anti-Human Polyclonal Antibody; PathPlus LRP2/Megalin Antibody; LRP2; DBS; Glycoprotein 330; gp330; Megalin; LRP-2; Calcium sensor protein; anti-LRP2 antibody
Host
Rabbit
Reactivity
Mouse, Rat, Human
Clonality
Polyclonal
Specificity
Recognizes endogenous levels of LRP2 protein.
Purity/Purification
Immunoaffinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-LRP2 antibody
WB (Western Blot), IHC (Immunohistochemistry)
Target
Human LRP2/Megalin
Immunogen
Recombinant full length protein of human LRP2
Conjugation
Unconjugated
Preparation and Storage
Aliquot and store at -20 degree C for 1 year. Avoid freeze/thaw cycles.
IHC (Immunohistochemisry)
(LRP2/Megalin Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohistochemisry)
(LRP2/Megalin Antibody-Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(LRP2/Megalin Antibody-Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
IHC (Immunohiostchemistry)
(LRP2/Megalin Antibody-Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE))
WB (Western Blot)
(LRP2/Megalin Antibody)
WB (Western Blot)
(LRP2/Megalin Antibody)
Related Product Information for anti-LRP2 antibody
Megalin antibody is an unconjugated rabbit polyclonal antibody to Megalin (LRP2) from human. It is reactive with human, mouse and rat. Validated for IHC and WB.
LRP2 (Megalin, low density lipoprotein-related protein 2) is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR). In immunohistochemistry, LRP2 has strongest membranous positivity in renal tubules in the kidney and in the parathyroid gland, followed by the brain, breast and placenta.
LRP2 (Megalin, low density lipoprotein-related protein 2) is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR). In immunohistochemistry, LRP2 has strongest membranous positivity in renal tubules in the kidney and in the parathyroid gland, followed by the brain, breast and placenta.
References
The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Nat. Genet. 39 (8): 957 -9, PMID: 17632512;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
521,958 Da
NCBI Official Full Name
low-density lipoprotein receptor-related protein 2
NCBI Official Synonym Full Names
LDL receptor related protein 2
NCBI Official Symbol
LRP2
NCBI Official Synonym Symbols
DBS; GP330
NCBI Protein Information
low-density lipoprotein receptor-related protein 2
UniProt Protein Name
Low-density lipoprotein receptor-related protein 2
UniProt Gene Name
LRP2
UniProt Synonym Gene Names
LRP-2; gp330
UniProt Entry Name
LRP2_HUMAN
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Product Notes
The LRP2 lrp2 (Catalog #AAA163221) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LRP2/Megalin Rabbit anti-Human Polyclonal Antibody reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's LRP2/Megalin can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the LRP2 lrp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LRP2/Megalin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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