Rabbit anti-Human, Mouse MDA5 Polyclonal Antibody | anti-MDA5 antibody

MDA5 Polyclonal Antibody

Cat. Num. AAA295204

• Gene Names: IFIH1; Hlcd; MDA5; MDA-5; RLR-2; IDDM19
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Synonyms: MDA5, Antibody; MDA5 Polyclonal Antibody; IFIH1; MDA5; RH116; Interferon-induced helicase C domain-containing protein 1; Clinically amyopathic dermatomyositis autoantigen 140 kDa; CADM-140 autoantigen; Helicase with 2 CARD domains; Helicard; Interferon-induced with helicase C domai; anti-MDA5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal

• Applicable Applications for anti-MDA5 antibody: IHC (Immunohistochemistry), WB (Western Blot)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

IHC (Immunohistochemistry)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)

IHC (Immunohiostchemistry)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)

WB (Western Blot)

(Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.)

Related Product Information for anti-MDA5 antibody

Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O- methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

NCBI and Uniprot Product Information

• NCBI GI #: 27886568
• NCBI GeneID: 64135
• NCBI Accession #: NP_071451.2
• NCBI GenBank Nucleotide #: NM_022168.3
• UniProt Accession #: Q9BYX4; Q2NKL6; Q6DC96; Q86X56; Q96MX8; Q9H3G6
• NCBI Official Full Name: interferon-induced helicase C domain-containing protein 1
• NCBI Official Synonym Full Names: interferon induced with helicase C domain 1
• NCBI Official Symbol: IFIH1
• NCBI Official Synonym Symbols: Hlcd; MDA5; MDA-5; RLR-2; IDDM19
• NCBI Protein Information: interferon-induced helicase C domain-containing protein 1; helicard; CADM-140 autoantigen; RIG-I-like receptor 2; helicase with 2 CARD domains; RNA helicase-DEAD box protein 116; murabutide down-regulated protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypept
• UniProt Protein Name: Interferon-induced helicase C domain-containing protein 1
• UniProt Gene Name: IFIH1
• UniProt Synonym Gene Names: MDA5; RH116; CADM-140 autoantigen; Helicard; MDA-5; RLR-2
• UniProt Entry Name: IFIH1_HUMAN