Rabbit MFN2 Polyclonal Antibody | anti-MFN2 antibody

MFN2 Antibody

Cat. Num. AAA40736

• Gene Names: MFN2; HSG; MARF; CMT2A; CPRP1; CMT2A2
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Purity: MFN2 antibody is affinity chromatography purified via peptide column.
• Synonyms: MFN2, Antibody; MFN2 Antibody; MFN2; HSG; MARF; CMT2A; CPRP1; CMT2A2; KIAA0214; Mitofusin-2; Transmembrane GTPase MFN2; mitofusin 2; anti-MFN2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MFN2 antibody is human, mouse and rat reactive. At least three isoforms of MFN2 are known to exist. MFN2 antibody is predicted to not cross-react with MFN1.
• Purity/Purification: MFN2 antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 757

• Applicable Applications for anti-MFN2 antibody: IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot), ELISA
• Conjugate: Unconjugated
• Immunogen: MFN2 antibody was raised against a 17 amino acid peptide near the center of human MFN2.
• Buffer: MFN2 antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: MFN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

IHC (Immunohistochemistry)

(Immunohistochemistry of MFN2 in mouse brain tissue with MFN2 antibody at 5 μg/mL.)

IF (Immunofluorescence)

(Immunofluorescence of MFN2 in mouse brain tissue with MFN2 antibody at 20 μg/mL.Green: MFN2 antibody (7863)Red: Phylloidin stainingBlue: DAPI staining)

IF (Immunofluorescence)

(Immunofluorescence of MFN2 in rat brain tissue with MFN2 antibody at 20 μg/mL.)

IHC (Immunohiostchemistry)

(Immunohistochemistry of MFN2 in rat brain tissue with MFN2 antibody at 5 μg/mL.)

WB (Western Blot)

(Western blot analysis of MFN2 in human brain tissue lysate with MFN2 antibody at 1 μg/ml.)

Related Product Information for anti-MFN2 antibody

Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3,4). Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5).

NCBI and Uniprot Product Information

• NCBI GI #: 7662004
• NCBI GeneID: 9927
• NCBI Accession #: NP_055689
• NCBI GenBank Nucleotide #: NM_014874.3
• UniProt Accession #: O95140; O95572; Q5JXC3; Q5JXC4; Q9H131; Q9NSX8; A8K1B3
• Molecular Weight: Predicted: 83 kDa; ; Observed: 90 kDa
• NCBI Official Full Name: mitofusin-2
• NCBI Official Synonym Full Names: mitofusin 2
• NCBI Official Symbol: MFN2
• NCBI Official Synonym Symbols: HSG; MARF; CMT2A; CPRP1; CMT2A2
• NCBI Protein Information: mitofusin-2; hyperplasia suppressor; transmembrane GTPase MFN2; mitochondrial assembly regulatory factor
• UniProt Protein Name: Mitofusin-2
• UniProt Gene Name: MFN2
• UniProt Synonym Gene Names: CPRP1; KIAA0214
• UniProt Entry Name: MFN2_HUMAN